持续冰帽亚低温治疗难治性癫痫持续状态的疗效和安全性观察

Efficacy and safety observation on sustained ice cap hypothermia treatment for refractory status epilepticus

目的:观察持续冰帽亚低温治疗难治性癫痫持续状态的疗效及安全性。方法:将60例患者随机分为观察组和对照组,每组各30例。观察组采用常规抗癫痫药物等治疗加局部冰帽亚低温治疗,对照组采用常规抗癫痫药物等治疗。观察比较两组疗效及不良反应发生率。结果:观察组总有效率80.00%,对照组总有效率63.33%,两组比较,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:持续冰帽亚低温治疗,有利于难治性癫痫持续状态的控制,较安全。

Objective: To observe the efficacy and safety of sustained ice cap mild hypothermia in the treatment of refractory status epilepticus. Methods: Sixty patients were randomly divided into observation group and control group,30 cases in each group. The observation group were treated by conventional anti-epileptic drugs,anti-infection treatment and local ice cap hypothermia. Control group were treated by conventional anti-epileptic drugs,anti-infection treatment. To observate and compare the efficacy and adverse reaction rate. Results: The total effective rate of treatment group was 80. 00%,control group was 63. 33%,there was significient difference( P < 0. 05). The incidence of adverse reactions in the two groups,the difference was not statistically significant( P > 0. 05). Conclusion: Sustained ice cap mild hypothermia treatment is conducive to the control of refractory status epilepticus,it is safer.