我院718例药品不良反应报告分析

Analysis of 718 cases of adverse drug reaction reported in our hospital

目的:了解我院药品不良反应(ADR)发生的特点及一般规律。方法:采用回顾性分析法对我院2012–2016年临床各科室收集上报至国家药品不良反应监测网的共计718例ADR监测报告内容进行详细分析。结果:718例ADR中,临床医护人员填报率28.41%,药学人员填报率71.59%;发生ADR患者女性(54.04%)略高于男性(45.96%);患者平均年龄(63.4±1.1)岁,老年患者发生率高;涉及的药物分类中,抗感染药物所致ADR发生率高(315例,37.59%),其中头孢类抗感染药物最多(134例);给药途径中,静脉滴注所致ADR发生率最高,占58.77%;ADR累及系统/器官以皮肤及其附件损害的占比最多(47.59%)。结论:我院ADR监测工作的深入开展,为临床提供了ADR方面的相关信息支持,进一步达到患者用药安全、有效的目的。

Objective：To investigate the characteristics and patterns of the adverse drug reactions（ADRs） in our hospital.Methods：A total of 718 ADR reports in our hospital from 2012 to 2016 were collected retrospectively.The data in respect of the reports involved in ADR were analyzed statistically.Results：Among the 718 cases,doctors and nurses reported 28.41%,pharmacists reported 71.59%.The incidence of ADR was slightly higher in women（54.04%） than that in men（45.96%）.The average age of the patients was（63.4 ± 1.1） year,the incidence of elderly patients was high.In the classification of drugs involved,the incidence of ADR anti-infective drugs was high（315 cases,37.59%） including 134 cases of cephalosporin anti-infective drugs.In the route of administration,the incidence of intravenous drip was the highest,accounting for 58.77%.In the system/organ damage,the most was the skin and its appendages damage,accounting for 47.59%.Conclusion：Our hospital ADR monitoring work carried out in depth,for the clinical information provided by the ADR support,further to achieve the purpose of safe and effective medication.