摘要
目的:探讨我院碳青霉烯类抗菌药物的应用情况和主要革兰阴性菌对其耐药率的相关性,为提高碳青霉烯类的合理应用提供理论依据。方法:采用回顾性调查的方法,统计2012–2016年碳青霉烯类抗菌药物的消耗金额、使用频度、占全部抗菌药物使用频度占比和4种革兰阴性菌对碳青霉烯类的耐药率,并将耐药率与使用频度占比进行线性回归分析。结果:2012–2016年期间,碳青霉烯类抗菌药物的销售金额增长了97.6%,总使用频度增长了111%,使用频度占比提高了41.5%,鲍曼不动杆菌对碳青霉烯类的耐药率与碳青霉烯类的使用频度占比呈显著正相关(r=0.888,P<0.05),铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌的耐药率与碳青霉烯类的使用频度占比之间无显著性相关(P>0.05)。结论:碳青霉烯类的使用对部分革兰阴性菌的耐药率变化影响较大,其临床应用需要加强管控。
Objective：To analyze the correlation between the utilization of carbapenem antibiotics and the drugresistance rates of some key gram-negative bacteria in our hospital,and provide a theoretical basis for improving the rational use of carbapenems.Methods：The data of consumption fee,DDDs,the DDDs proportion in all antibiotics of carbapenem,and the drug-resistance rates of four gram-negative bacteria to carbapenem from 2012 to 2016 were retrospectively analyzed,and the correlation between drug-resistance rates and drug use was conducted by linear regression.Results：During the past fi ve years,the consumption fee,DDDs,and the DDDs proportion in all antibiotics of carbapenem increased 97.6%,111% and 41.5%,respectively.The drug-resistant rate of Acinetobacter baumanii to carbapenem had a signifi cant positive correlation with the DDDs proportion of carbapenem in all antibiotics（r = 0.888,P 〈 0.05）.All the drug-resistance of Pseudomonas aeruginosa,Escherichia coli and Klebsiella pneumonia to carbapenem did not have signifi cant correlation with the DDDs proportion（P 〉 0.05）.Conclusion：The consumption of carbapenem antibiotics had signifi cant effect on the drug-resistance of some gram-negative bacteria,and the use of carbapenems in clinic should be administrated intensively.
出处
《中国药物应用与监测》
CAS
2017年第6期361-364,共4页
Chinese Journal of Drug Application and Monitoring
基金
上海市临床药学重点专科建设项目(2016-40044-002)
上海市卫生计生系统重要薄弱学科建设项目(2016ZB0303)
