氟尿嘧啶致严重口腔黏膜炎1例

Severe oral mucositis induced by fluorouracil

1例38岁女性患者,清宫术后5个月余,病理检查结果为"侵蚀性葡萄胎"。术后末次氟尿嘧啶注射液单药化疗后,主因严重口腔黏膜炎3 d入院。入院诊断为"侵蚀性葡萄胎Ⅲ期低危化疗后"、"严重口腔黏膜炎"。患者口腔黏膜多处破溃严重,少许出血点,无法进食,口齿不清,初始治疗给予康复新液(10 m L,bid,po),重组人表皮生长因子外用溶液(4000 IU,qd,外用)对症支持治疗,同时给予肠外营养及相关感染指标检测,加强口腔清洁。3 d后患者口腔黏膜炎有所好转,继续原方案治疗。6 d后患者情况明显好转,可进流食,停用肠外营养药物。14 d后患者情况基本恢复正常,口齿清晰,可正常进食,当日出院。

A 38-year-old female patient who had an operation of uterus curettage about 5 months ago was diagnosed as invasive hydatidiform mole according to the pathology.The patient received infusion of fl uorouracil last time after operation and admitted to hospital for severe oral mucositis for 3 days.The diagnosis was invasive hydatidiform mole Ⅲ stage with low risk,severe oral mucositis.The patient had severe oral ulceration with bleeding spots,inability to eat,slurred speech.The initial treatment was Kangfuxin liquid（10 m L,bid,po）,recombinant human epidermal growth factor external solution（4000 IU,qd,external use） for symptomatic support treatment,at the same time,the patient was given parenteral nutrition and the related infection indexes were detected,the oral cavity cleaning was strengthened.After 3 days,the oral mucositis improved,the initial treatment was continued.After 6 days,the patient’s condition was obviously improved,with liquid diet,the parenteral nutrition was discontinued.After 14 days,the patient almost recovered to normal condition,with normal diet,and discharged from hospital.