环磷腺苷葡胺治疗老年慢性充血性心力衰竭患者的临床效果分析

Clinical analysis of cyclophosphate adenosine monophosphate in elderly patients with chronic congestive heart failure

目的探究老年慢性充血性心力衰竭患者通过环磷腺苷葡胺治疗后所存在的应用价值。方法选取老年慢性充血性心力衰竭患者80例,划分标准依据随机分组标准进行,分为观察组和对照组,各40例。对照组和观察组治疗方法分别为常规西医治疗和环磷腺苷葡胺治疗。结果在心功能分级及6分钟步行情况方面,观察组均优于对照组(P<0.05),观察组有55.0%的患者心功能等级为Ⅰ级,而对照组仅有37.5%的患者为Ⅰ级;观察组治疗后的左心室射血分数为(48.53±5.62)、心输出量为(5.75±0.54),其每搏输出量为(79.53±6.43),这些数据均优于对照组,差异具有统计学意义(P<0.05);观察组治疗后NT-proBNP浓度为(314.45±11.32)pg/ml,显著优于对照组(398.75±23.63)pg/ml,差异具有统计学意义(P<0.05);观察组C-反应蛋白改善情况显著优于对照组,其中,观察组患者的C-反应蛋白为(9.03±1.02),而对照组为(10.89±2.26),差异具有统计学意义(P<0.05);但是两组治疗前后肝肾功能各指标变化比较,差异无统计学意义。结论老年慢性充血性心力衰竭患者通过环磷腺苷葡胺治疗后,使患者心功能、NT-proBNP浓度及C-反应蛋白改善均显著改善,存在一定推广价值。

Objective To explore the application value of cisplatin in elderly patients with chronic congestive heart failure.Methods 80 elderly patients with chronic congestive heart failure were selected.The criteria were divided into the observation group and the control group according to the randomized grouping criteria.The control group and the observation group were treated by conventional western medicine and cyclophosphate adenosine monotherapy.Results In the case of cardiac function grade and 6-minute walking,the observation group was superior to the control group(P<0.05).In the observation group,55.0% of the patients had gradeⅠcardiac function and only 37.5% in the control group,The left ventricular ejection fraction of the observation group after treatment was(48.53±5.62),the cardiac output was(5.75±0.54)and the stroke volume was(79.53±6.43).The data were better than those in the control group(P<0.05),and the left ventricular ejection fraction(P<0.05).The concentration of NT-proBNP in the observation group was(314.45±11.32) pg/ml,which was significantly better than that in the control group(398.75±23.63),and the difference was statistically significant(P<0.05).The improvement of C-reactive protein in the observation group was significantly better than that in the control group.The C-reactive protein in the observation group was(9.03±1.02),and the difference was statistically significant(P<0.05),while the control group was(10.89±2.26),the two groups of data were significantly different;but the two groups before and after treatment of liver and kidney function changes in the indicators,the difference was not statistically significant.Conclusion The improvement of heart function,NT-proBNP concentration and C-reactive protein in elderly patients with chronic congestive heart failure after treatment with cyclic adenosine monophosphate are significantly improved.