不同剂量醒脑静对不同严重程度脑溢血患者的疗效及对患者Hcy和血糖水平的影响

The effect of different doses of Xingnaojing Injection on patients with different severity of cerebral hemorrhage and the effect on the blood glucose level and Hcy

目的考察不同剂量的醒脑静对不同严重程度脑溢血患者的疗效及对患者Hcy和血糖水平的影响。方法收集急性脑溢血患者249例,按入院顺序分为两组:对照组121例,醒脑静治疗组128例。结果两组治疗过程中无明显的不良反应。与对照组比,醒脑静治疗组的轻、中和重度总有效例较多(P<0.05),其中轻和中度的痊愈例数较多(P<0.05)。两组不同严重程度的脑溢血治疗前的Hcy和血糖水平比较差异无统计学意义,治疗后,Hcy和血糖均有不同程度的降低(P<0.05),与对照组比,醒脑静治疗组的轻度、中度和重度的Hcy和血糖水平均显著降低(P<0.05)。结论对较为严重的脑溢血需给予高剂量的醒脑静,醒脑静可通过降低Hcy和血糖水平达到治疗脑溢血的目的。

Objective To investigate the effect of different doses on homocysteinemina(Hcy) and plasma glucose in different severity of stroke.Methods 249 case acute stroke patients enrolled into our study and divided into 2 groups:121 cases as the control group and 128 cases Xingnaojing group.Results There had no significant adverse reactions during treatment in 2 groups.Compared with the control group,in the Xingnaojing group,more cases in light,moderate and severe subgroups were recovery(P<0.05).There had no significant differences in Hcy and plasma glucose in 2 groups before treatment.After treatment,Hcy and plasma glucose had decreased in 2 groups.Compared with the control group,Hcy and plasma glucose in the Xingnaojing group,more cases in light,moderate and severe subgroups had decreased significantly(P<0.05).Conclusion The higher dose of Xingnaojing can treat the severe acute stroke by lowering Hcy and plasma glucose.