两种不同药物联合治疗小儿哮喘的疗效观察

Observation on the curative effect of two different drugs combined with treatment of asthma in children

目的研究两种不同药物联合治疗小儿哮喘的疗效。方法回顾90例小儿哮喘患儿,根据治疗方法不同分两组,每组45例,对照组采用药物氨茶碱治疗;联合治疗组采用硫酸镁与氨茶碱联合治疗。就两组患儿哮喘症状消除时间、住院时间和哮喘治疗疗效、不良反应、3个月复发率、治疗前后哮喘控制测试评分、气峰值流速、肺活量、第1秒用力呼气容积等指标进行比较。结果联合治疗组哮喘治疗疗效93.33%明显高于对照组73.33%,差异具有统计学意义(P<0.05)。联合治疗组不良反应2.22%明显和对照组4.44%比较,差异无统计学意义。联合治疗组3个月复发率2.22%明显低于对照组17.78%,差异具有统计学意义(P<0.05)。联合治疗组患儿哮喘症状消除时间、住院时间(0.54±0.15)d、(3.02±1.53)d均明显短于对照组(2.24±1.11)d、(5.98±1.72)d,差异具有统计学意义(P<0.05)。治疗前两组哮喘控制测试评分、气峰值流速、肺活量、第1秒用力呼气容积等指标相近,差异无统计学意义;治疗后联合治疗组患儿哮喘控制测试评分、气峰值流速、肺活量、第1秒用力呼气容积等指标优于对照组,差异具有统计学意义(P<0.05)。结论硫酸镁与氨茶碱联合治疗小儿哮喘的疗效确切,可有效控制哮喘,缩短疗程,改善肺功能,降低复发率,用药安全性较高,联合用药不增加副作用,是小儿哮喘理想用药方案,值得推广。

Objective To study the efficacy of two different drugs in the treatment of children with asthma.Methods 90 children with asthma were reviewed.According to different treatment methods,45 patients in each group were treated with aminophylline.The combination therapy was treated with magnesium sulfate and aminophylline.The two groups of children with asthma symptoms,hospitalization and asthma treatment efficacy,adverse reactions,3-month recurrence rate,before and after treatment of asthma control test scores,peak gas flow rate,vital capacity,forced expiratory volume of the first 1 and other indicators were compared.Results The results add some important specific data.Treatment group was 93.33%higher than that of the control group(73.33%),the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(2.22%) and 4.44% in the control group.The recurrence rate was 2.22% in the 3-month group and 17.78% in the control group,the difference was statistically significant(P<0.05).(0.54±0.15) d and(3.02±1.53) d were significantly shorter than those in the control group(2.24±1.11) days and(5.98±1.72) d,the difference was statistically significant(P<0.05).There were no significant differences in the scores of asthma control test,peak gas flow rate,vital capacity and forced expiratory volume in the first two groups before treatment.The difference between the two groups was statistically significant.After treatment,the asthma control test score,peak gas flow rate,vital capacity(P<0.05).The difference between the two groups was statistically significant(P<0.05).Conclusion The combination of magnesium sulfate and aminophylline in the treatment of children with asthma is effective,can effectively control asthma,shorten the course of treatment,improve lung function,reduce the recurrence rate,drug safety is high,combined with no side effects,is the ideal medication for children with asthma,Worthy of promotion.