醋酸钙联合高通量低钙透析治疗尿毒症患者高磷血症临床研究

Clinical study of calcium acetate combined with high flux and low calcium dialysis in the treatment of hyperphosphatemia in uremic patients

目的:探讨醋酸钙与高通量低钙透析治疗尿毒症患者高磷血症的效果。方法:收治维持性血液透析治疗尿毒症患者80例,随机分为观察组及对照组。对照组采用碳酸钙治疗,观察组采用醋酸钙并联合高通量低钙透析治疗,比较两组治疗效果。结果:治疗后,观察组血钙、血磷及i PTH水平均显著低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:尿毒症维持性血液透析患者加以醋酸钙联合高通量低钙透析治疗,利于稳定患者血钙水平,患者的血磷水平和i PTH水平显著降低,对预防患者高磷血症的发生有重要价值。

Objective:To explore the clinical effect of calcium acetate combined with high flux and low calcium dialysis in the treatment of hyperphosphatemia in uremic patients.Methods:80 cases of uremic patients treated with maintenance hemodialysis were selected.They were randomly divided into the observation group and the control group.The control group was treated with calcium carbonate.The observation group was treated by calcium acetate combined with high flux and low calcium dialysis.We compared the therapeutic effect of two groups.Results:After treatment,the levels of serum calcium,phosphorus and i PTH in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion:The application of calcium acetate combined with high flux and low calcium dialysis in the treatment of uremic patients treated with maintenance hemodialysis was beneficial to stabilize the serum calcium level.Serum phosphorus levels and i PTH levels were significantly decreased in the patients.It had important value in preventing the occurrence of hyperphosphatemia.