羟考酮对宫颈癌手术术后镇痛效果及IL-6、IL-10影响的研究

Analgesic effect of oxycodone after cervical cancer surgery and its effect on IL-6 and IL-10

目的:探讨羟考酮对腹腔镜下宫颈癌手术术后镇痛的效果及IL-6、IL-10的影响。方法:收治行腹腔镜宫颈癌手术ASA分级Ⅰ~Ⅱ级患者60例,随机分为试验组和对照组。试验组采用羟考酮,对照组采用吗啡。结果:两组在各时间点生命体征差异无统计学意义(P>0.05);试验组术后2 h、4 h、8 h、24 h的VAS评分和不良反应发生率明显低于对照组(P<0.05);术毕、术后4 h、8 h、24 h两组IL-6、IL-10的水平均高于诱导前,且对照组升高水平高于试验组(P<0.05)。结论:羟考酮对宫颈癌手术术后镇痛效果佳,其对免疫方面的抑制作用优于吗啡。

Objective:To explore the analgesic effect of oxycodone after laparoscopic surgery for cervical cancer and its effect on IL-6 and IL-10.Methods:60 patients of ASA grade with Ⅰ to Ⅱ grade treated with laparoscopic surgery for cervical cancer were selected.They were randomly divided into the experimental group and the control group.The experimental group was treated with oxycodone,and the control group was treated with morphine.Results:There was no significant difference in vital signs between groups at each time point(P>0.05).In the experimental group,the postoperative VAS score at 2 hours,4 hours,8 hours,24 hours and the incidence of adverse reactions were significantly lower than those of the control group(P<0.05).The levels of IL-6 and IL-10 in the two groups at after operation point,at 4 hours,8 hours,24 hours after operation were higher than those before induction,and the level of reduction in the control group was higher than that in the experimental group(P<0.05).Conclusion:The analgesic effect of oxycodone after laparoscopic surgery for cervical cancer was better.Its inhibitory effect on immunity was superior to that of morphine.