高尿酸血症与心血管疾病危险因素的相关性分析

Relationship analysis between hyperuricemia and related risk factors of cardiovascular disease

目的研究高尿酸血症(HUA)与心血管疾病(CVD)危险因素的相关性。方法选取在本院体检中发现的高尿酸血症患者300例作为观察组,尿酸正常体检者300例作为对照组。比较两组的心血管危险因素水平:体质量指数(BMI)、血压、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并探究血清尿酸水平与心血管各危险因素间的关系。结果观察组的血压、TC、TG及LDL-C水平均明显高于对照组,而HDL-C低于对照组,差异有统计学意义(P<0.05);多元线性回归分析表明,血清尿酸水平与收缩压(SBP)、舒张压(DBP)、TC、TG呈正相关关系,与HDL-C呈负相关关系(P<0.05)。结论高尿酸血症与心血管疾病危险因素密切相关,并且会增加心血管疾病病发的风险。

Objective To study the relationship between hyperuricemia and the related risk factors of cardiovascular disease.Methods 300 patients with hyperuricemia who had health check in our hospital were selected as the observation group,and another 300 cases with normal uric acid were selected as the control group. And the related risk factors of cardiovascular disease were compared between the two groups,including body mass index（ BMI）,blood pressure,fasting blood glucose（ FBG）,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL-C）,and low density lipoprotein cholesterol（ LDL-C）. And the relationship between the level of serum uric acid and the related risk factors of cardiovascular disease was discussed. Results The levels of blood pressure,TC,TG and LDL-C in the observation group were significantly higher than those in the control group,while HDL-C was lower than that in the control group,and the differences were statistically significant（ P〈 0. 05）. The results of linear correlation analysis revealed that the level of serum uric acid was in a positive correlation with SBP,DBP,TC,and TG,while in a negative correlation with HDL-C,and the differences were statistically significant（ P〈 0. 05）. Conclusion Hyperuricemia is associated with the related risk factors of cardiovascular disease,and can increase the risk of cardiovascular disease.