广泛性焦虑障碍患者心理健康、人格特征与免疫功能的关系

The correlation among mental health,personality characteristics and immune function of patients with generalized anxiety disorder

目的探讨广泛性焦虑障碍患者心理健康、人格特征与免疫功能的关系。方法选取我院收治的广泛性焦虑障碍(GAD)患者56例作为观察组,另选取我院同期体检健康人员50例作为对照组,采用焦虑自评量表(SAS)和抑郁自评量表(SDS)、艾森克人格问卷简版(EPQ-RSC)分别对两组患者的心理健康与人格特征状况进行评估。另检测两组患者的血清白介素-2(IL-2)、CD3^+、自然杀伤细胞(NK),并对观察组心理健康、人格特征与免疫功能的相关性进行分析。结果观察组SAS、SDS各个条目及总分显著高于对照组(P<0.05);观察组EPQ-RSC量表中内外倾向分量表(E)、心理变态分量表(P)、效度量表(L)评分与对照组比较差异无统计学意义(P>0.05),观察组情绪性量表(N)与EPQ-RSC总分均显著高于对照组(P<0.05);观察组IL-2水平显著高于对照组(P<0.05),CD3^+、NK水平显著低于对照组(P<0.05);相关分析结果显示:SAS、SDS、EPQ-RSC与IL-2呈正相关,与CD3^+、NK均呈负相关。结论 GAD患者焦虑和抑郁情绪较健康人群明显,且存在神经质倾向的人格特征,此类患者的免疫功能也有受损的现象。

Objective To explore the correlation between mental health,personality characteristics and immune function of patients with generalized anxiety disorder.Methods 56 patients with generalized anxiety disorder（GAD）treated in our hospital were selected and assigned to the observation group,and 50 healthy people who had physical examination were assigned into the control group.Mental health and personality characteristics of both groups were evaluated using Self-rating Anxiety Scale（SAS）,Self-rating Depression Scale（SDS）,and Eysenck Personality Questionnaire（EPQ-RSC）,and serum interleukin-2（IL-2）,CD3~＋,natural killer cells（NK）were examined using relevant test.For the observation group,the correlation between mental health,personality and immune function was analyzed after all the tests.Results The score of each item and the total score of SAS and SDS of the observation group were significantly higher than those of the control group（P〈0.05）;there was no statistical difference in the scores of E,P,L between the observation group and the control group（P〈0.05）.The score of N and total score of EPQ-RSC of the observation group were significantly higher than those of the control group（P〈0.05）.IL-2 level of the observation group was significantly higher than that of the control group（P〈0.05）,while level of CD3~＋ and NK were significantly lower than those of the control group（P〈0.05）.Correlation analysis showed that the scores of SAS,SDS and EPQ-RSC were positively correlated with IL-2 level,and were negatively correlated with CD3~＋ and NK levels.Conclusion GAD patients have statistically higher anxiety and depression level than their healthy counterpart,and have neurotic tendency in terms of personality characteristics.Such patients can also have an impaired immune function.