大剂量醛氢叶酸加5-FU持续静脉滴注治疗晚期贲门癌的初步研究

High-Dose-Folinic Acid and 5-fluorouracil Bolus Continuous 48-Hour Infusion in the treatment of Advanced Cardiac Cancer

目的 :评价大剂量醛氢叶酸加 5 FU持续 4 8h滴入为主方案治疗晚期贲门癌的客观疗效及毒副反应 ,探索晚期贲门癌较合理治疗方案。方法 :对入选的 2 7例晚期贲门癌患者采用大剂量醛氢叶酸+ 5 FU持续 4 8h滴入为主方案进行治疗 ,平均 2 89个疗程。结果 :完全缓解 (CR) 1例 ,部分缓解(PR) 10例 ,稳定 (NC) 12例 ,进展 (PD) 4例 ,有效率为 4 0 74 %。主要的毒副反应为恶心呕吐、口腔黏膜炎、骨髓抑制、脱发及腹泻。上述毒副作用除恶心呕吐较明显外 ,其余绝大多数均为Ⅰ～Ⅱ度反应 ,且发生率不高 ,经常规对症治疗后见好转。结论 :大剂量醛氢叶酸 + 5 FU持续 4 8h滴注为主方案治疗晚期贲门癌疗效好 。

Objective To assess the anti-tumor efficacy and safety of high-dose-folinic acid and 5-fluorouracil bolus continuous 48-hour infusion in the treatment of advanced cardiac cancer.Methods Twenty-seven patients with advanced cardiac cancer were treated by high-dose-folinic acid and 5-fluorouracil bolus continuous 48-hour infusion.Results There were one complete esporse,ten partial response,twelve no changes and four progressive disease in the series with total response rate of 40.74%. The main side effects included nausea and vomiting,mucositis,bone marrow suppression,alopecia and diarrhea.Other side effects were uncommon.All side effects were tolerable and mild except for nausea-vomiting.Conclusions High-dose-folinic acid and 5-fluorouracil bolus plus 48-hour continuous infusion may be a safe and effective therapy for the patients with advanced cardiac cancer.