镇江地区2108例支气管肺炎患儿呼吸道病毒病原学分析

Etiological analysis of respiratory viruses in 2108 children with bronchopneumonia in Zhenjiang area

目的探讨镇江地区2108例支气管肺炎患儿的呼吸道病毒病原学和流行病学特征。方法取2108例支气管肺炎患儿鼻咽分泌物,采用荧光标记的呼吸道病毒单克隆抗体检测常见呼吸道病毒,分别为流感病毒(IFV)、副流感病毒(PIV)、呼吸道合胞病毒和腺病毒。结果 2108例标本中,病毒阳性检出率为55.26%(1165/2108);其中,IFV-B型检出率为55.31%,IFV-A型为24.53%,PIV-3型为14.28%。IFV-A型和IFV-B型男性患儿检出例数多于女性患儿,而PIV-3型女性患儿检出例数多于男性患儿(P<0.01或P<0.05)。IFV-A型和IFV-B型检出例数均以1岁~和3岁~组最多(P<0.05);PIV-1型、PIV-2型及PIV-3型检出例数均以3岁~组最多(P<0.05)。IFV-A型和IFV-B型在秋、冬季检出例数多于春、夏季(P<0.05);PIV-3型夏、秋、冬季检出例数均多于春季(P<0.05)。结论 IFV-A型、IFV-B型和PIV-3型病毒是镇江地区幼儿及学龄前儿童支气管肺炎的主要病原体。

Objective To analyze the etiological characteristics of respiratory viruses in 2108 children with bronchopneumonia in Zhenjiang area China.Methods Using fluorescent-labeled respiratory virus monoclonal antibody,common respiratory viruses,such as influenza virus（IFV）,parainfluenza virus（PIV）,respiratory syncytial virus and adenovirus in Nasopharyngeal secretion samples from 2108 children with bronchopneumonia were detected.Results The positive rate of respiratory viruses was 55.26%（1165/2108）,which was 55.31% for IFV-B,24.53% for IFV-A and14.28%for PIV-3.The numbers of cases with IFV-A and IFV-B in boys were more than those in girls,which of cases with with PIV-3 were more in girls than those in boys（P〈0.01 or P〈0.05）.The numbers of cases with IFV-A and IFV-B were more in groups of age more than one year and more than three years（P〈0.05）.The numbers of cases with PIV-1,PIV-2 and PIV-3 were more in group of age more than three years（P〈0.05）.The IFV-A and IFV-B were detected more commonly seen in autumn and winter.The PIV-3 was more commonly seen in summer,autumn and winter.Conclusion Most common pathogens for bronchopneumonia in infants and preschool children in Zhenjiang district are types of IFV-A,IFV-B and PIV-3 viruses.