环状RNA的功能及与心血管疾病的关系

Functions of circular RNAs and the relationship with cardiovascular diseases

环状RNA(circular RNA,circRNA)是继微小RNA(microRNA,miRNA)和长链非编码RNA(long noncoding RNA,lncRNA)之后一种新兴的内源性非编码RNA(noncoding RNA,ncRNA),在最近几年逐渐受到广泛关注,是目前RNA研究的热点。近年来越来越多的研究者发现,circRNA参与了心血管疾病的发生发展,它在调控心血管疾病中的巨大潜能,提示其在临床诊断和治疗方面具有广阔的前景。本文将从circRNA的特征、主要功能及其与心血管疾病的关系等方面对近年来国内外的研究进展作一综述。

Circular RNA （circRNA） is an emerging noncoding RNA （ncRNA） after microRNA （miRNA） and long noncoding RNA （IncRNA） recently, and it has attracted more and more attentions. In recent years, more and more researchers have found that circRNA is involved in the occurrence and development of cardiovascular diseases, and it has a great potential in the regulation of cardiovascular diseases, suggesting that it has broad prospects in clinical diagnosis and treatment. In this paper, we review the recent advances in the research of circRNAs from the aspects of their characteristics, main fnnctions and the relationship with cardiovascular diseases.