OSAHS患者病情程度影响因素分析

Influencing factor analysis of the degree of obstructive sleep apnea-hypopnea syndrome patients

目的分析阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)病情减轻与加重的影响因素。方法采用Pearson相关系数分析2013年1月至2015年1月本院收治的71例不同程度的OSAHS患者的体征、血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平、多导睡眠记录监测指标、心脏结构及肺动脉压等临床资料。结果 OSAHS患者的病情程度与VEGF水平、体质指数(body mass indes,BMI)、氧减指数、最长氧减时间、肺动脉高压及心脏结构异常均呈正相关(r=0.276、0.755、0.256、0.274、0.747、0.645,P_均<0.05),与颈围和腰围均无相关性(r=1.864,P=1.638),与夜间最低脉搏血氧饱和度(pulse oxygen saturation,SpO_2)呈负相关(r=-0.263,P=0.017)。结论 OSAHS患者BMI、VEGF水平、AHI及氧减指数越高,最长氧减时间越长,夜间最低SpO_2越低,病情越严重,症状越明显,并发肺动脉高压出现心脏结构异常的风险越大,需及早采取相应的预防措施。

Objective To explore the influencing factor of the degree of obstructive sleep apnea-hypopnea syndrome（OSAHS） patients. Method Pearson correlation coefficient was used to analyze the signs, serum vascular endothelial growth factor（VEGF） level, poly somno graphy（PSG） monitoring index, cardiac structure and pulmonary arterial pressure in 71 patients with varying degrees of OSAHS from January 2013 to January 2015. Result The degree of OSAHS was positively correlated with VEGF level, body mass index（BMI）, oxygen desaturation index, the longest oxygen desaturation time, pulmonary hypertension and cardiac structural abnormalities（r = 0.276, 0.755, 0.256, 0.274, 0.747, 0.645, P（all） 0.05）, there was no correlation between the degree of OSAHS and the neck circumference and waist circumference（r = 1.864, P = 1.638）, the degree of OSAHS was negative correlated with pulse oxygen saturation（SpO2）（r =-0.263, P = 0.017）. Conclusion OSAHS patients with higher BMI, AHI, oxygen desaturation index and VEGF level, the longer oxygen desaturation time, the lower SpO2, the more serious of the condition, the more obvious of the symptoms, the greater of the risk of cardiac structural abnormalities associated with pulmonary hypertension, it is necessary to take appropriate preventive measures as soon as possible.