普拉克索与美多芭合用配合心理治疗应用于帕金森病合并睡眠障碍患者的效果

The effect of pramipexole and meidoba joint psychological treatment on Parkinson′s disease with sleep disorders

目的探讨普拉克索与美多芭合用配合心理治疗应用于帕金森病合并睡眠障碍患者的效果。方法按抽签法将96例帕金森病合并睡眠障碍患者分为对照组与研究组,每组48例,两组均行心理治疗,对照组予以美多芭治疗,研究组在对照组基础上加以普拉克索治疗,观察两组治疗后运动症状、睡眠质量、生活质量变化,临床疗效和不良反应。结果治疗后,研究组帕金森统一评分量表(UPDRS)、UPDRSⅡ、UPDRSⅢ评分均低于对照组,差异有统计学意义(P<0.05)。研究组爱泼沃斯嗜睡量表、匹兹堡睡眠质量指数量表评分均低于对照组(P<0.05)。研究组39项帕金森病生活质量问卷高于对照组(P<0.05);研究组总有效率(98.58%)高于对照组(79.06%),研究组不良反应率(29.16%)低于对照组(56.25%),差异均有统计学意义(P<0.05)。结论普拉克索、心理治疗合用美多芭治疗帕金森病合并睡眠障碍患者的临床疗效好,但仍需要多中心随机对照试验加以证实。

Objective To research the effect of pramipexole and meidoba joint psychological treatment on Parkinson′s disease with sleep disorders.Methods 96 patients with Parkinson′s sleep disorder were divided into control group and research group by lottery method,all the 48 cases,both groups were treated by psychotherapy,control group treatmented by meidoba,the research group based on the control group treatmented by pramipexole,the symptoms,sleep quality,quality of life change,clinical efficacy and adverse reactions between the two groups after treatment were observed.Results After treatmented,the unified Parkinson′s disease rating scaleⅡ,Ⅲ(UPDRS Ⅱ,UPDRS Ⅲ)of research group was lower than those in the control group,the differences were statistically significant(P<0.05).The Ewworth Sleepiness Scale,Pittsburgh sleep quality index scale of research group was lower than those in the control group(P<0.05).The 39 Parkinson′s quality of life questionnaire of research group was higher than that in the control group(P<0.05).The total effective rate of research group was higher than that in the control group(98.58%vs.79.06%),the adverse reaction rate of research group was lower than that in the control group(29.16%vs.56.25%,P<0.05).ConclusionPramipexole and meidoba joint psychological in treatment Parkinson′s disease combines sleep disorders with good clinical efficacy,but still need multi-center randomized controlled trial to be confirmed.