类风湿关节炎合并心血管疾病的研究进展

Research progress on the risk of cardiovascular disease in patients with rheumatoid arthritis

类风湿关节炎(RA)患者心血管疾病(CVD)的风险高于年龄和性别相匹配的一般人群的1.5~2.0倍。因全身慢性炎症导致的心血管风险增高是RA的特征之一。RA最优化心血管风险管理的挑战包括改进预测心血管风险的方法和确定目标危险因素以减少心血管风险。从RA研究中吸取经验教训,对于一般人群同样收益,因为炎症在动脉粥样硬化的发病机制中有着重要作用。

The risk of cardiovascular disease in patients with rheumatoid arthritis is 1.5-fold and 2. 0-fold higher than matched general population. This excess risk is attributed to the systemic chronic innammation which is a hallmark of RA. Challenges to optimizing CV risk management in RA include the need for improved methods to predict CV risk,and defining the target risk factors to reduce CV risk. Lessons learned from RA studies can also inform CV risk prevention in the general population, where inflammation also plays an important role in the pathogenesis of atherosclerosis.