Toll样受体4(896A/G)基因多态性与溃疡性结肠炎易感性的Meta分析

Association between the polymorphism ( 896A/G) of TLR4 gene and susceptibility of ulcerative colitis: a Meta-analysis

目的研究Toll样受体4(TLR4)896A>G位点基因多态性与溃疡性结肠炎(UC)发病风险的关系。方法检索相关英文及中文数据库筛选文献,以OR值及95%CI为效应指标,运用Rev Man 5.2和Stata 11.0进行Meta分析和敏感性分析,并采用Egger's test评价发表偏倚。结果研究共纳入14篇文献,包括2 174例UC患者和3 134例对照者。Meta分析结果表明携带等位基因G的人群较携带等位基因A的人群患UC的风险性增加,在各个基因模型下均差异有统计学意义[等位基因模型G/A:OR=1.41,95%CI(1.21~1.66),P<0.000 1;显性模型AG+GG/AA:OR=1.37,95%CI(1.16~1.62),P=0.000 2;隐性模型GG/AA+AG:OR=3.74,95%CI(1.78~7.86),P=0.000 5;共显性模型AG/AA:OR=1.42,95%CI(1.07~1.87),P=0.01;共显性模型GG/AA:OR=3.85,95%CI(1.82~8.12),P=0.000 4]。亚组分析结果表明,在等位基因模型G/A、显性模型AG+GG/AA、共显性模型AG/AA下,差异仅在白种人中存在。结论 TLR4 896A>G基因多态性与UC易感性相关,携带等位基因G会增加白种人患UC的发病风险。由于该研究纳入有关亚洲人群及非洲人群的文献数量较少,相关结果需要更多研究予以验证。

Objective To study the relationship between toll like receptor 4( TLR4) 896 A > G polymorphism and the risk of ulcerative colitis( UC). Methods The English and Chinese database were searched to screen the relevant literatures. Rev Man 5. 2 and Stata 11. 0 software were used for the meta-analysis and sensitivity analysis,the odds ratio( OR value) and 95% confidence interval( 95%CI) were calculated. Egger's test was used for publication bias. Results A total of 14 articles were included in the study with 2174 UC patients and 3134 controls. Meta-analysis showed that compared with allele A,the allele G increased the risks of ulcerative colitis significantly[allele model G/A: OR = 1. 41,95% CI( 1. 21-1. 66,P < 0. 000 1); dominant model AG + GG/AA: OR = 1. 37,95% CI( 1. 16-1. 62,P = 0. 000 2); recessive model GG/AA + AG: OR = 3. 74,95% CI( 1. 78-7. 86),P = 0. 000 5; co-dominant model AG/AA: OR =1. 42,95% CI( 1. 07-1. 87),P = 0. 01; co-dominant model GG/AA: OR = 3. 85,95% CI( 1. 82-8. 12),P = 0. 000 4]. But,the results of subgroup analysis showed that the differences only existed among caucasians in allele model G/A,dominant model AG + GG/AA and co-dominant model AG/AA. Conclusions TLR4 896 A > G polymorphism is associated with the susceptibility of ulcerative colitis,and the allele G increases the risks of ulcerative colitis significantly in caucasians. Due to the limited quantity of the included studies about Asian and African population,further studies are needed to validate our findings.