银杏达莫联合高压氧治疗高血压脑出血术后的疗效观察

Clinical efficacy of Yinxingdamo injection combined with high pressure oxygen in the treatment of hypertensive cerebral hemorrhage after mini-invasive evacuation of hematoma

目的观察银杏达莫注射液联合高压氧治疗微创血肿清除术后高血压脑出血的临床疗效及其安全性。方法选取94例行微创血肿清除术的高血压脑出血患者作为研究对象,采用随机数字表法将其分为观察组及对照组。对照组给予高压氧治疗;观察组在对照组治疗的基础上另给予银杏达莫注射液治疗,两组治疗时间均为14 d。治疗后对患者疗效进行评价;治疗前后分别检测各组患者血管外周阻力(R)、动态阻力(DR)、脑血管平均流速(Vmean)和脑血管平均流量(Qmean)等脑血管功能水平,并观察各组患者NIHSS评分、Fugl-Meyer运动功能评价量表及格拉斯哥昏迷指数(GCS)评分。结果观察组总有效率为85.1%,明显高于对照组(P<0.05)。两组患者治疗后脑血管功能指标、NIHSS、Fugl-Meyer及GCS评分均得到明显改善(P<0.05),且治疗后观察组上述指标的改善程度明显优于对照组(P<0.05)。结论银杏达莫注射液联合高压氧治疗高血压脑出血微创血肿清除术后具有较好的疗效,值得进行深入探讨。

Objective To study the clinical efficacy of Yinxingdamo injection combined with high pressure oxygen in the treatment of hypertensive cerebral hemorrhage after mini-invasive evacuation of hematoma. Methods Ninety-four hypertensive cerebral hemorrhage patients undergoing mini-invasive evacuation of hematoma were selected and randomly assigned into observation group and control group. Control group was treated with high pressure oxygene while observation group was given additional Yinxingdamo injection. The courses of treatments of two groups were both 14 days. The effects were observed and the levels of peripheral resistance( R),dynamic resistance( DR),average cerebral blood flow rate( Vmean),and average cerebral blood flow( Qmean) were detected in the two groups,and the NIHSS,Fugl-Meyer and GCS scores were evaluated in the patients. Results The total effective rate of observation group was 85. 1%,significantly higher than that in control group( P < 0. 05). After the treatment,the levels of R,DR,Vmean,Qmean,NIHSS,Fugl-Meyer and GCS scores were significantly improved in the two groups( P < 0. 05),which were more obvious in the observation group( P < 0. 05). Conclusions Yinxingdamo injection combined with high pressure oxygen has better clinical efficacy in the treatment of hypertensive cerebral hemorrhage after mini-invasive evacuation of hematoma,which is worth to be further studied.