脓毒症新常态及其治疗研究进展

Research Progress of the New Norm of Sepsis and Its Treatment

脓毒症是一项全球性公共卫生问题,其发病率、死亡率持续居高。虽然进行了大量研究,但至今未能完全阐述其病理生理机制。随着医疗技术进步和社会人口结构变化,脓毒症的临床表现及病理生理也在发生转变。因此充分了解脓毒症新的发展变化对临床诊治具有重要意义。近年来发现免疫应答在脓毒症发生、发展中具有重要作用,对脓毒症免疫应答的研究有希望成为未来诊治的突破口。现总结近年来国内外相关文献,阐述脓毒症的新发展变化及相应治疗的研究进展。

Sepsis is a global public health problem because of increased morbidity and mortality. Although there are a lot of researches,we still can not fully explain the pathophysiological mechanism. With the progress of medical technology and the change of social population structure,the clinical phenotype and pathophysiology of sepsis have been changing. Therefore,it is important to fully understand the new normal of sepsis for diagnosis and treatment. In recent years,it has been found that immune response plays an important role in the pathogenesis of sepsis, and the study of immune response will become a promising breakthrough in the diagnosis and treatment of sepsis in the future. This paper summarizes the domestic and foreign literature published in recent years,expounds the latest research progress of the new changes in sepsis and its therapy.