氯丙嗪和氯氮平对精神分裂症血清细胞因子水平的影响

Serum Levels of cytokines and psychopathology in schizophrenia:effects of neuroleptic treatment

目的 探讨精神分裂症症状与细胞因子 (CK)的关系 ,了解抗精神病药物对CK的影响。方法 用ELISA法检测2 4例精神分裂症患者治疗前后及 16名正常人的血清白细胞介素 2 (IL 2 )及其可溶性受体 (sIL 2R)、а 肿瘤坏死因子 (TNFа)及其可溶性受体Ⅰ (sTNF RⅠ )、受体Ⅱ (sTNF RⅡ )、IL 10水平 ,同时采用简明精神病量表 (BPRS)评估患者精神症状。结果 治疗前血清sIL 2R、sTNF RⅠ、sTNF RⅡ、IL 10水平显著高于正常。氯氮平治疗IL 10显著下降。某些CK的变化与BPRS因子分的变化存在高度相关。结论 提示精神分裂症存在CK介导的免疫功能异常 ,CK的变化是精神症状演变的一个参考指标。氯氮平可能通过抑制IL

Objective To investigate the association between CKs and symptoms and effects of neuroleptic treatment. Methods Serum levels of IL 2,sIL 2R, TNFа,sTNF RⅠ,sTNF RⅡ were measured by ELISA in 24 schizophrenic patients before and during at least 4 weeks of neuroleptic treatment and in 16 healthy subjects.The severity of symptoms in schizophrenia was assessed by BPRS. Results Serum levels of sIL 2R,sTNF RⅠ,sTNF RⅡ and IL 10 were significantly lower after treatment with clozapine. Some CK alterations were correlation with reductions in some BPRS factors. Conclusion The findings suggest immunologic abnormalities in schizophrenia.CK alterations may represent a available marker of psychotic variations.The clozapine may exert immuno suppressive effects by decreasing IL 10 levels.