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益气活血解毒汤联合西药治疗糖尿病肾病Ⅳ期随机平行对照研究 被引量:5

Randomized Parallel Controlled Study of Yiqi Huoxue Jiedu combined with Western Medicine in the Treatment of Diabetic Nephropathy
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摘要 [目的]观察益气活血解毒汤联合西药治疗糖尿病肾病Ⅳ期疗效。[方法]使用随机平行对照方法,将60例住院及门诊患者按就诊顺序号简单随机分两组。对照组30例贝那普利10mg,1次/d,不能耐受或使用ACEI,改为缬沙坦80mg,1次/d。治疗组30例益气活血解毒汤(黄芪30g,山药20g,山萸肉15g,葛根20g,红花10g,丹参15g,水蛭10g,土茯苓、积雪草各20g,牛蒡、猫爪草各15g),1剂/d,煎取2袋,150mL/袋,早晚各一袋,饭后30min服用;西药治疗同对照组。连续治疗30d为1疗程。观测临床症状、尿蛋白定量、CysC、CRP、BUN、Scr、不良反应。治疗1疗程,判定疗效。[结果]治疗组完全缓解4例,基本缓解5例,好转19例,无效3例,总有效率90.00%;对照组完全缓解2例,基本缓解2例,好转16例,无效10例,总有效率66.67%;治疗组疗效优于对照组(P<0.05)。尿蛋白定量、CysC、CRP改善治疗组优于对照组(P<0.01)。[结论]益气活血解毒汤联合西药治疗糖尿病肾病Ⅳ期,疗效满意,无严重不良反应,值得推广。 [Objective] To observe the effect of Yiqi Huoxue Jieji Decoction combined with western medicine on the treatment of diabetic nephropathy. [Methods] 60 cases of hospitalized and outpatient patients were randomly divided into two groups according to the order of treatment using random parallel control method. The control group of 30 cases of benazepril 10 mg, 1 times/d, can not tolerate or use ACEI, to valsartan 80 mg, 1 times/d. Treatment group of 30 cases of Qi and blood circulation detoxification method(Astragalus 30 g, yam 20 g, cornus 15 g, Pueraria 20 g, safflower 10 g, Salvia 15 g, leeches 10 g, Smilax, Centella asiatica 20 g, burdock, cat claw grass 15 g), 1 dose/d, fried 2 bags, 150 m L/bag, sooner or later a bag, 30 min after taking meals; Western medicine with the control group. Continuous treatment for 30 days for a course of treatment. Observation of clinical symptoms, urinary protein quantification, CysC, CRP, BUN, Scr, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group had complete remission in 4 cases, 5 cases of basic remission, 19 cases improved, 3 cases were ineffective, the total effective rate was 90.00%; the control group completely relieved 2 cases, 2 cases of basic remission, 16 cases improved, 10 cases, The effective rate was 66.67%; the treatment group was better than the control group(P0.05). Urine protein was quantified, and CysC and CRP improved the treatment group better than the control group(P0.01). [Conclusion] Yiqi Huoxue Jiedu combined with western medicine in the treatment of diabetic nephropathy Ⅳ, the effect is satisfactory, no serious adverse reactions, it is worth promoting.
出处 《实用中医内科杂志》 2017年第11期40-43,共4页 Journal of Practical Traditional Chinese Internal Medicine
关键词 糖尿病肾病Ⅳ期 益气活血解毒汤 贝那普利 缬沙坦 尿蛋白定量 CYSC CRP BUN Scr 中西医结合治疗 随机平行对照研究 diabetic nephropathyIV Yiqi Huoxue Jiedu method benazepril valsartan urine protein quantification CysC CRP BUN Scr Combination of traditional Chinese and western medicine random parallel controlled study
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