石辛含片联合碘甘油治疗智齿冠周炎的疗效观察

Clinical observation of Shixin Buccal Tablets combined with iodine glycerol in treatment of pericoronitis

目的探讨石辛含片联合碘甘油治疗智齿冠周炎的临床疗效。方法选取2016年4月—2017年4月在解放军第101医院进行诊治的智齿冠周炎患者160例,随机分为对照组(80例)和治疗组(80例)。对照组患者将碘甘油涂于牙周袋,3次/d。治疗组在对照组的基础上于牙患处含化石辛含片,1片/次,4次/d。两组患者均治疗5 d。观察两组患者临床疗效,比较治疗前后两组OHIP-14和VAS评分以及菌群变化情况。结果治疗后,对照组和治疗组临床总有效率分别为83.75%、96.25%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者OHIP-14和VAS评分均显著降低,同组比较差异具有统计学意义(P<0.05);且治疗组患者OHIP-14和VAS评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组细菌密度、格兰阴性菌比例、螺旋体比例均明显降低,而格兰阳性菌比例增加,同组比较差异具有统计学意义(P<0.05);且治疗组菌群变化情况明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论石辛含片联合碘甘油治疗智齿冠周炎可有效改善患者口腔健康,具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy of Shixin Buccal Tablets combined with Iodine Glycerol in treatment of pericoronitis. Methods Patients（160 cases） with pericoronitis in the 101 st Hospital of PLA from April 2016 to April 2017 were randomly divided into control（80 cases） and treatment（80 cases） groups. Patients in the control group were given iodine glycerol to the pouch of periodontium, three times daily. Patients in the treatment group were po administered with Shixin Buccal Tablets on the basis of the control group, 1 tablet/time, four times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, OHIP-14 and VAS scores, and the changes of microflora in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.75% and 96.25%, respectively, and there were differences between two groups（P〈0.05）. After treatment, the OHIP-14 and VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And OHIP-14 and VAS scores in the treatment group were significantly lower than that in the control group, with significant difference between two groups（P〈0.05）. After treatment, the bacterial density, G-bacteria ratio and spirochaeta ratio in two groups was significantly decreased, and there were differences in the same group（P〈0.05）. And the change of microflora in the treatment group was significantly better than that in the control group, with significant difference between two groups（P〈0.05）. Conclusion Shixin Buccal Tablets combined with iodine glycerol in treatment of pericoronitis can effectively improve the oral health, which has a certain clinical application value.