卡泊三醇软膏联合钙泊三醇倍他米松软膏治疗慢性湿疹的疗效观察

Clinical observation of Calcipotriol Ointment combined with Calcipotriol Betamethasone Ointment in treatment of chronic eczema

目的探讨卡泊三醇软膏联合钙泊三醇倍他米松软膏治疗慢性湿疹的临床疗效。方法选取2015年1月—2017年1月徐州市中心医院收治的慢性湿疹患者102例为研究对象,按照数表法将患者随机分为对照组(50例)和治疗组(52例)。对照组患处涂抹钙泊三醇倍他米松软膏,10 g/次,1次/d,1周用量不超过100 g。治疗组在对照组的基础上涂抹卡泊三醇软膏,5 g/次,2次/d,1周用量不超过100 g。两组患者均连续治疗8周。观察两组的临床疗效,比较两组的临床体征评分、皮肤生理功能、复发和不良反应情况。结果治疗后,对照组和治疗组的总有效率分别为86.0%、96.2%,两组比较差异有统计学意义(P<0.05)。治疗后,两组红斑、浸润和肥厚、抓痕、苔藓化、湿疹面积及严重程度指数(EASI)评分明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组经表皮水分流失(TEWL)明显降低,角质层含水量(WCSC)、皮肤油脂(SC)明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组复发率和内分泌紊乱、局部疼痛、局部萎缩的发生率明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论卡泊三醇软膏联合钙泊三醇倍他米松软膏治疗慢性湿疹具有较好的临床疗效,可改善临床症状,调节皮肤生理功能,降低疾病复发率,且安全性较好,具有一定的临床推广应用价值。

Objective To study the effect of Calcipotriol Ointment combined with Calcipotriol Betamethasone Ointment in treatment of chronic eczema. Methods Patients（102 cases） with chronic eczema in Xuzhou Central Hospital from January 2015 to January 2017 were randomly divided into control group（50 cases） and treatment group（52 cases）. Patients in the control group were smear on the lesion with Calcipotriol Betamethasone Ointment, 10 g/time, once daily, and the dosage of 1 week was not more than 100 g. Patients in the treatment group were smear on the lesion with Calcipotriol Ointment on the basis of the control group, 5 g/time, twice daily, and the dosage of 1 week was not more than 100 g. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom score, skin physiological function, recurrence, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 86.0% and 96.2%, respectively, and there was difference between two groups（P〈0.05）. After treatment, the scores of erythema, infiltration, hypertrophy, scratches, moss, eczema area, and EASI in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly loeer than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the TEWL in two groups were significantly decreased, but the WCSC and SC in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. The recurrence rate, endocrine disorders, local pain and local atrophy in the treatment group were significantly lower than those in the control group, and the differences were statistically significant between two groups（P〈0.05）. Conclusion Calcipotriol Ointment combined with Calcipotriol Betamethasone Ointment has clinical curative effect in treatment of chronic eczema, can improve clinical symptoms, regulate skin physiological function, and decrease the recurrence rate of the disease, with good safety, which has a certain clinical application value.