两种方式输注恩度联合化疗治疗晚期非小细胞肺癌效果观察

Efficacy of two ways of infusion of Endostar combined with chemotherapy on advanced non small cell lung cancer

目的比较两种方式输注恩度联合化疗治疗晚期非小细胞肺癌患者的疗效。方法选取40例晚期非小细胞肺癌患者,根据输注方式分为观察组和对照组,每组20例。观察组行恩度持续静脉泵入联合化疗治疗,对照组采取静脉滴注恩度联合化疗治疗。比较两组临床疗效、生活质量及不良反应发生情况。结果观察组治疗后有效率和疾病控制率均高于对照组(P均<0.05)。对照组血液学毒性反应及心脏毒性发生率高于观察组(P<0.05);治疗后两组生活质量比较,差异未见统计学意义(P>0.05)。结论恩度输注方式对晚期非小细胞肺癌治疗效果有一定的影响。持续静脉泵入恩度更利于药物的吸收,且不良反应少。

Objective To compare the effect of two ways of infusion of endostar combined with chemotherapy in the treatment of patients with advanced non small cell lung cancer. Methods Forty pa- tients with advanced non small cell lung cancer were selected and divided into the observation group and the control group according to the infusion method, with 20 cases in each group. Patients in the observa- tion group were given continuous intravenous infusion of Endostar combined with chemotherapy, and pa- tients in the control group received intravenous infusion of Endostar combined with chemotherapy. The clinical efficacy, quality of life and adverse reactions of the two groups were compared. Results The ef- ficiency and disease control rate of observation group were higher than those of control （P 〈 0.05）. The incidence of hematologic toxicity and cardiac toxicity of control group were higher than those of observa- tion group （P 〈 O. 05 ）. The difference of quality of life after the treatment between the two groups was not significant （P 〉 0. 05）. Conclusions The way of infusion of Endostar has a certain impact in the treatment of advanced non small cell lung cancer. Continuous intravenous infusion of Endostar is more conducive to the absorption of the drug, has fewer adverse reactions.