血浆脑钠肽水平在不同类型冠心病中的变化及其临床意义

Clinical significance of plasma brain natriuretic peptide in patients with different types of coronary heart disease

目的探讨血浆脑钠肽(BNP)在不同类型冠心病(CHD)中的变化及其临床意义。方法选取已行冠状动脉造影确诊为冠心病患者100例,根据患者临床表现分为急性心肌梗死组(AMI组,30例)、稳定型心绞痛组(SAP组,28例)、不稳定型心绞痛组(UAP组,42例)。另选取同期冠状动脉造影正常的健康人20例为健康对照组。分析各组BNP水平的差异。结果 AMI组BNP水平较UAP组升高[(543.45±22.43)ng/L比(190.42±11.21)ng/L],UAP组BNP水平较SAP组升高[(190.42±11.21)ng/L比(32.34±5.23)ng/L],差异有统计学意义(P<0.05)。SAP组BNP水平与健康对照组比较差异未见统计学意义[(32.34±5.23)ng/L比(31.68±5.32)ng/L]。结论 BNP参与冠心病的发生及发展,并对冠心病的诊断治疗和危险分级有一定的指导意义。

Objective To investigate the changes of plasma brain natriuretic peptide （BNP） in dif- ferent types of coronary heart disease and its clinical significance. Methods One hundred patients with coro- nary angiography diagnosed as coronary heart disease （CHD） were selected as coronary heart disease group, and 20 healthy patients with normal coronary angiography were selected as control group. The patients in coro- nary heart disease group were divided into acute myocardial infarction group （30 cases）, stable angina pecto- ris group （28 cases） and unstable angina group （42 cases） according to the clinical manifestations. The differences of BNP levels were studied. Results The level of BNP in AMI group was significantly higher than that of UAP group[ （543. 45±22. 43 ）ng/L vs. （ 190. 42 ＋_ 11.21 ） ng/L） ]. The level of BNP in UAP group was significantly higher than that of the SAP group [ （ 190. 42 ± 11.21 ） ng/L vs （32. 34 ± 5.23 ） ng/L） ], the differences were significant （P 〈 0. 05 ）. There was no significant difference in BNP level between the stable angina group and the control group { （ 32. 34 ± 5.23 ） ng/L vs. （ 31.68 ± 5.32 ） ng/L ） ]. Conclusion BNP is involved in the development and progression of coronary heart disease and has some significance for the diagnosis and treatment of coronary heart disease and risk stratification.