摘要
目的研究外伤性癫痫致痫灶α-螺旋结构蛋白质的红外光谱改变。方法利用傅里叶红外光谱面扫描成像技术对大鼠外伤性癫痫脑组织标本进行检测,获得α-螺旋结构的光谱数据,以及红外光谱图像。结果致痫灶可见明显的α-螺旋结构高吸收区,高吸收区色差与吸收度与低吸收区存在明显不同。结论外伤性癫痫致痫灶广泛存在α-螺旋结构跨膜蛋白的改变,具有α-螺旋结构的跨膜蛋白广泛参与了外伤性癫痫的发生。
Objective The article is to study on the detection of α-helix proteins in post-traumatic epileptogenic focus by FTIR-mapping.Methods Fourier transform infrared spectroscopy-mapping were applied to identifying α-helix by point-by-point scanning in post-traumatic epileptogenic focus sections and to develop FTIR-mapping profiles.Result The high absorbance of α-helix is accord with post-traumatic epilepsy,there are some significant differences between high absorbance and low absorbance.Conclusion α-helix proteins are distributed in post-traumatic epileptogenic focus widely,thus α-helix protein are involved in post-traumatic epilepsy.
出处
《中国法医学杂志》
CSCD
2017年第6期583-587,共5页
Chinese Journal of Forensic Medicine
基金
北京市优秀人才培养资助项目(2013D002023000002)
中国政法大学青年教师学术创新团队资助项目(2016CXTD05
2014CXTD04)