芩柏颗粒保留灌肠治疗湿热蕴结型溃疡性结肠炎37例临床观察

Clinical effect of retention enema with Qinbai granules in treatment of ulcerative colitis with damp-heat accumulation:an analysis of 37 cases

目的:观察芩柏颗粒保留灌肠治疗湿热蕴结型溃疡性结肠炎的临床疗效。方法:将73例湿热蕴结型溃疡性结肠炎患者随机分为治疗组37例和对照组36例,对照组予美沙拉嗪缓释颗粒治疗,治疗组在对照组基础上联合芩柏颗粒保留灌肠治疗,均以4周为1个疗程,治疗3个疗程后比较2组临床疗效及生活质量评分。结果:临床疗效总有效率和结肠镜疗效总有效率治疗组分别为91.9%、94.6%,对照组分别为72.2%、77.8%,组间比较,差异均有统计学意义(P<0.05);2组生活质量评分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:芩柏颗粒保留灌肠治疗湿热蕴结型溃疡性结肠炎有较好疗效。

Objective：To investigate the clinical effect ofretention enema with Qinbai granules in the treatment ofulcerative colitis with damp-heat accumulation.Methods：A total of 73 patients with ulcerative colitis with damp-heat accumulation were randomly divided into treatment group with 37 patients and control group with 36 patients.The patients in the control group were given mesalazine sustained-release granules,and those in the treatment group were given retention enema with Qinbai granules in addition to the treatment in the control group.Each course of treatment was 4 weeks,and the two groups were compared in terms of clinical outcome and quality of life score after three courses of treatment.Results：There were significant differences between the treatment group and the control group in the overall response rates for clinical outcome（91.9% vs 72.2%,P0.05） and colonoscopic findings（94.6% vs 77.8%,P0.05）.Both groups had a significant change in quality of life score after treatment,and there was a significant difference in quality of life score between the two groups after treatment（P0.05）.Conclusion：Retention enema with Qinbai granules has a good clinical effect in the treatment of ulcerative colitis with damp-heat accumulation.