低频重复经颅磁刺激治疗精神分裂症幻听的效果

Effect of low frequency repetitive transcranial magnetic stimulation in treatment of schizophrenia

目的探讨低频重复经颅磁刺激治疗精神分裂症幻听的效果。方法将120例精神分裂症幻听患者随机分成对照组(n=65,假刺激治疗)和观察组(n=55,低频重复经颅磁刺激治疗),对比2组患者PANSS量表中各因子评分和不良反应发生情况。结果观察组患者治疗2周末、4周末以及6周末的阳性症状、一般精神病理、幻听评分以及麻木感发生概率(3.34%)、头痛发生概率(5.45%)均低于对照组(P<0.05),阴性症状治疗前后未发生明显变化(P>0.05)。结论低频重复经颅磁刺激治疗精神分裂症幻听安全有效。

Objective To investigate the effect of low frequency repetitive transcranial magnetic stimulation in the treatment of auditory hallucination of schizophrenia.Methods A lot of 120 patients with auditory hallucination of schizophrenia were randomly divided into a control group（n=65, sham treatment） and an observation group（n=55, low frequency repetitive transcranial magnetic stimulation）, and each factor score of PANSS scale and adverse reactions were compared between two groups.Results Two weeks, four weeks, and six weeks after the treatment, the positive symptoms, general psychopathology, auditory hallucination score, numbness probability（3.34%）, and headache occurrence probability（5.45%） in the observation group were lower than those in the control group（P 0.05）, but the negative symptoms did not change significantly before and after the treatment（P 0.05）. Conclusion Low frequency repetitive transcranial magnetic stimulation is safe and effective in the treatment of auditory hallucination of schizophrenia.