血清蛋白因子水平对精神分裂症的诊断价值

Values of serum protein factors in diagnosis of schizophrenia

目的探究血清蛋白因子水平对精神分裂症诊断价值。方法收取本院75例精神分裂症患者作为观察组,再选择本院健康体检者作为对照组,将2组的神经胶质原纤维酸性蛋白(GFAP)、干扰素-γ(IFN-γ)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、钙结合蛋白(S100β)、髓鞘碱性蛋白(MBP)、血清神经生长因子(NGF)、血清脑源性神经营养因子(BDNF)水平进行对比。结果观察组GFAP、IL-6、S100β、MBP、NGF、BDNF水平与对照组相比差异有统计学意义(P<0.05),IFN-γ水平(17.01±4.60)ng/L、TNF-α(18.64±3.40)ng/L,与对照组相比差异无统计学意义(P>0.05)。结论血清蛋因子水平与精神分裂症临床表现以及病理生理密切相关,对精神分裂症诊断具有十分重要的意义,能为患者症状以及诊断提供客观性指标评价。

Objective To investigate the diagnostic value of serum protein factor levels in the patients with schizophrenia.Methods A total of 75 schizophrenia patients were selected as an observation group, and the healthy persons were selected as a control group. The neurokeratin fibrillary acidic protein（GFAP）, interferon-γ（IFN-γ）, tumor necrosis factor a（TNF-α）, interleukin 6（IL-6）, calcium binding protein（S100β）, myelin basic protein（MBP）, serum nerve growth factor（NGF）, and brain-derived neurotrophic factor（BDNF） levels were detected and the results were compared between two groups.Results There were significant differences between the two groups in GFAP, IL-6, S100β, MBP, NGF and BDNF levels（all P0.05）. In the observation group, IFN-γ level [（17.01 ±4.60） ng/L） and TNF-a level [（18.64±3.40）ng/L] had no significant differences compared with those in the control group（both P0.05）. Conclusion The serum protein factor levels are closely related to the clinical manifestations and pathophysiology of schizophrenia, which are of great significance in the diagnosis of schizophrenia.