血清钙水平与带状疱疹性神经痛的相关性研究

Correlation between the serum calcium and herpes zoster neuralgia

目的:探讨带状疱疹性神经痛患者血清钙水平及其与患者疼痛程度之间是否存在关联。方法:将我院疼痛科2015年8月至2016年9月44例临床诊断为带状疱疹性神经痛(herpes zoster neuralgia,HZN)的患者归为带状疱疹性神经痛组(HZ组,n=44),再根据患者不同疼痛程度把44例患者细分为轻度疼痛组(n=10)、中度疼痛组(n=26)、重度疼痛组(n=8);同时选择未罹患带状疱疹的普通体检患者为阴性对照组(C组,n=40)。收集患者疼痛评分、血清钙的检测资料。结果:(1)HZ组血清钙离子浓度(2.28±0.09)mmol/L比C组(2.38±0.05)mmol/L明显降低且有统计学意义(t=5.720,P=0.000)。(2)HZ组患者不同钙离子浓度分组之间不同疼痛程度的患病人数有统计学意义(χ2=10.94,P=0.027)。血清钙浓度降低,中度以上疼痛程度的患者数量增加,轻度疼痛患者数量减少。(3)血清钙离子浓度和疼痛程度呈负相关(r=-0.50,P=0.001)。(4)HZ组轻度疼痛组患者血清钙离子浓度(2.37±0.09)mmol/L高于中度疼痛组患者血清钙离子浓度(2.26±0.08)mmol/L,具有统计学意义(P=0.010);同时较重度疼痛组患者血清钙离子(2.23±0.07)mmol/L浓度高,且具有统计学意义(P=0.010)。结论:带状疱疹感染时期患者血清钙水平降低,血清钙水平决定疱疹疼痛程度。随着血清钙水平降低,疼痛程度加重。

Objective：To explore the concentration of serum calcium in herpes zoster neuralgia（HZN）patient and the relevance between the concentration and the pain degree.Methods：All of the 44 patients in our pain department from August 2015 to September2016 were collected into herpes zoster group,who were diagnosed with herpes zoster neuralgia（HZ group,n=44）.Then the 44 patients were divided into mild pain group（n=10）,moderate pain group（n=26）and severe pain group（n=8）according to their different pain degree.While 40 patients on P.E.who were diagnosed with no herpetic infection were collected as control group（C group,n=40）.A retrospective study on the data of serum calcium as well as the degree of pain was conducted.Results：（1）The concentration of serum calcium of HZ group were lower than that of control group [（2.28±0.09） mmol/L vs.（2.38±0.05） mmol/L,t =5.720,P =0.000].（2）There was a significant difference in number of patients with different pain degrees between different calcium levels in HZ group.With the decrease of the serum calcium level,the number of patients with pain degree beyond moderate was on the increase,while that of patients with mild pain degree was on the decrease.（3）In HZ group,it demonstrated a negative correlation between the level of serum calcium and pain degree（r=-0.50,P=0.001）.（4）In HZ group,serum calcium level of mild pain group was higher than that of moderate pain group[（2.37±0.09）mmol/L vs.（2.26±0.08）mmol/L,P=0.010].There was a significant difference of serum calcium level between mild pain group and severe pain group [（2.37±0.09）mmol/L vs.（2.23±0.07）mmol/L,P=0.010].Conclusion：During the stage of herpes zoster,the concentration of the serum calcium is decreased.The pain degree is depended on the level of serum calcium.With the decreasing of serum calcium level the pain degree is on the increase.