延续性护理对NSCLC患者口服EGFR-TKI所致皮疹的影响

Effect of continuous care on EGFR-TKI induced rash in patients with NSCLC

目的:观察延续性护理对非小细胞肺癌(NSCLC)患者口服表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)所致皮疹的改善情况及生活质量的影响。方法:选取64例口服吉非替尼或厄洛替尼后出现皮疹的患者,采用随机数字表法分成观察组和对照组,每组32例,对照组出院后通过电话随访了解患者的皮肤情况及生活质量;观察组在电话随访的基础上予以延续性护理。对比分析不同护理方法对两组患者皮疹改善情况及生活质量的影响。结果:观察组患者在皮疹改善情况及生活质量方面明显优于对照组患者(P<0.05)。结论:延续性护理方法可明显改善NSCLC患者口服EGFR-TKI所致皮疹,并提高患者的生活质量,值得临床推广应用。

Objective：To observe the effect of continuity nursing on skin rash caused by non-small-cell carcinoma （ NSCLC ） patients taking epidermal growth factor receptor tyrosine kinase inhibitors （ EGFR-TKI ） orally. Methods：To select 64 patients with rash after oral administration of gefitinib or elotinib, and the patients were divided into the observation group and the control group by using the random number table method. After discharge, the observation group were given continuity of care, and the control group did not take any intervention measures. We followed up the skin conditions and quality of life of patients by telephone, and compared the rash improvement and life quality improvement of different nursing methods for the two groups of patients.Result： Patients in the observation group were significantly better than the control group in the improvement of skin rash and quality of life. Conclusion：The continuity nursing method can obviously improve the skin rash caused by NSCLC patients taking EGFR-TKI orally, and improve the quality of life of patients.