基于血脑屏障药物渗透机制的建模与分析

Modeling and Analysis of Drug Permeation Mechanism Based on Blood-Brain Barrier

由于血脑屏障结构的特殊性,脑内疾病的治疗仍然是临床诊疗的一个难点。一般情况下,病人只能通过口服或注射药物来治疗这类疾病。采用理论分析和数值模拟相结合的方法,在控制药物毒性最小的前提下,研究血管和脑组织中游离药物浓度随时间的变化情况。在比较分析未加入超声和加入超声的两个模型后发现:未加入超声时,毛细血管和脑组织中的游离药物浓度在140 min左右达到平衡状态,且平衡点处的药物浓度很低,达不到治疗效果;而加入超声后,在60~70 s就达到了稳定,同时达到稳态时药物浓度也明显增加。由此可见:加入超声大大减少了服药后大脑组织中药物达到治疗浓度所需的时间,且增加了进入脑组织的药物量。

Treatment for the intracerebral diseases has been a challenging issue in clinical diagnosis and treatment. Because of the special brain barrier structure,patients generally treat these diseasesonly through oral or injection drugs. In order to make it clear,this paper theoretically and numerically studies the variation laws of free drug concentration in the vascular and brain tissue given minimizing the toxicity of drugs. After comparing two models without and with ultrasound treatments,we find that at the absence of ultrasound treatment it takes about 140 minutes that the concentration of free drugs in capillary and brain tissue reaches the balance state. In this case,drug concentration is greatly low,which does not achieve an ideal therapeutic effect. Otherwise,it only takes approximately 60 to 70 minutes to reach the balance state with ultrasound treatments and drug concentration significantly increases. That greatly reduces the time taken for drugs to reach therapeutic concentration in brain tissue and increases the amount of drugs entering the brain tissue.