PDCD4与MMP-7在胃癌组织中的表达及临床意义

Expression and clinical significance of PDCD4 and MMP-7 protein in human gastric carcinoma

目的探讨PDCD4和MMP-7在胃癌组织中的表达及其与临床病理特征的关系。方法选择手术切除的胃癌组织标本70例,采用免疫组织化学SP法检测70例胃腺癌及癌旁组织的PDCD4和MMP-7的表达水平,探讨其与临床病理学参数的关系。结果在胃癌组织中MMP-7呈高表达,显著高于对照组(78.6%vs.22.9%,P<0.05),而PDCD4呈低表达,显著低于对照组(31.4%vs.75.7%,P<0.05);PDCD4和MMP-7表达均与淋巴结转移、腹腔内转移、浸润深度、临床分期存在显著相关性(P<0.05)。经Pearson相关性分析显示,PDCD4与MMP-7表达具有负相关性(r=-0.526,P=0.000)。结论胃癌组织中PDCD4表达降低、MMP-7表达增高与胃癌的发展以及侵袭有关,可能共同参与了调控作用。

Objective To investigate the expression and significance of PDCD4 and MMP-7 in human gastric carcinoma （GC） tissues and to analyze their association with clinical pathological characteristics in GC patients. Methods Immunohistochemieal staining SP was used to detect the expression of PDCD4 and MMP-7 protein in gastric cancer specimens and para-carcinoma tissue in 70 cases, and the relationship with clinical pathological characteristics were analyzed. Results The expression rate of MMP-7 in GC tissues in the study group was high and significantly higher than that in the control group （78.6% vs. 22.9%, P 〈0.05）, while the expression rate of PDCD4 protein was low and significantly lower than that in the control group （31.4% vs. 75.7% , P 〈0.05）. Both the expressions of PDCIM and MMP-7 were significantly associated with tumor lymph node metastasis, peritoneal metastasis, the depth of invasion and late clinical stage of GC （P〈0.05）. The correlation analysis indicated that there was a negative correlation between the expressions of PDCD4 and MMP-7 （ r = - 0. 526, P = 0. 000）. Conclusion The expression of PDCIM and MMP-7 might be correlated to the carcinogenesis and invasion, and might be involved in the GC regulation.