系统免疫炎症指数与老年食管癌预后的关系

Effects of systemic immune -inflammation indexes on the prognosis of elderly patients with esophageal cancer

目的评价系统免疫炎症指数（systemic immune-inflammation index，SII）对老年食管癌患者放疗后预后评估的价值，并将SII和血小板淋巴细胞比值（PLR）、单核细胞淋巴细胞比值（MLR）与患者预后的关系进行比较。方法回顾性分析84例首次行放疗的老年食管癌患者的临床资料，利用ROC曲线确定SII、PLR、MLR的最佳界值，并分析SII、PLR和MLR与患者预后的关系。结果全组84例患者的中位生存时间为19个月。SII和PLR与老年食管癌放疗患者的生存有关（P〈0．05），MLR与患者的生存无关（P=0．22）。根据ROC曲线下面积，SII对患者总生存时间的预测价值优于PLR（P〈0．05）。结论SII是老年食管癌患者放疗后的有效预测指标，SII值较高的患者预后较差。

Obiective To evaluate the application of systemic immune - inflammation indexes （SII） in assessing the prognosis of elderly patients with esophageal cancer after radiotherapy. Methods Clinical data were collected from 84 patients who received radiotherapy before retrospective analysis. The cutoff values of SII, platelet - lymphocyle ratio （PLR） and monocyte -lymphocyte ratio （MLR） were determined by ROC curve, and the relationship between SII, PLR and MLR was analyzed. Results The median overall survival （OS） time was 19 months for all patients. SII and PLR in elderly patients with esophageal cancer were associated with OS （ P 〈 0.05 ）, rather than MLR （ P = 0.22）. According to the area under the ROC curve, the predictive value of SII was superior to that of PLR （P 〈 0.05）. Conclusions SII is a strong predictive index for elderly patients with esophageal cancer after radiotherapy. The higher SII is, the worse the prognosis will become.