血清FGF23和klotho水平与血液透析患者血管钙化的关系

Relationship between serum FGF23 and klotho levels and vascular calcification in hemodialysis patients

目的探讨血清成纤维细胞生长因子（FGF）23和klotho水平与血液透析患者血管钙化的关系。方法选取2016年1月-2017年3月我院收治的血液透析治疗患者，共65例。采用酶联免疫吸附技术测定患者血清FGF23和klotho的水平，并采用X线片检测腹主动脉、股动脉与桡动脉部位的血管钙化情况。结果本组患者血清FGF23水平明显高于健康体检者值，血清klotho水平显著低于健康体检者值，差异有统计学意义（P〈0．05）。X线检测显示，65例患者中有42例患者存在不同程度、不同部位的血管钙化情况，其中21例为轻度钙化、11例为中度钙化、10例为重度钙化。中、重度钙化患者的血清FGF23和klotho水平与轻度患者相比存在显著性差异（P〈0．05）。结论血液透析患者普遍存在血管钙化的情况，而血清FGF23和klotho水平是影响血管钙化的独立危险因素。

Objective To investigate the relationship between serum fibroblast growth factor- 23 （FGF23） and klotho levels and vascular calcification in hemodialysis patients. Methods A total of 65 patients who were admitted into our hospital from January 2016 to March 2017 due to hemodialysis were selected. The levels of serum FGF23 and klotho were measured by enzyme- linked immunosorbent assay （ELISA）. X -ray was used to detect vascular calcification in the abdominal aorta, femoral and radial arteries. Results The patients showed remarkable increases in the levels of ser- um FGF23 and klotho, compared with the normal values （P 〈 0.05 ）. According to X - ray examination, there were 42 patients with vascular calcification at different sites to various degrees, including 21 mild cases, 11 moderate cases and 10 severe cases. There was significant difference in serum FGF23 and klotho levels between mild vascular calcification patients and those in moderate to severe conditions （P 〈 0. 05 ）. Conclusions Vascular calcification is prevalent in he- modialysis patients, and serum FGF23 and klotho levels are independent risk factors for vascular calcification.