舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究

Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading

目的:观察基质金属蛋白酶9(MMP-9)在舍格伦综合征病人唾液中的表达情况,分析其与组织病理分级的相关性,探讨唾液中MMP-9水平作为舍格伦综合征特异性标志物的可能性。方法:采集27例舍格伦综合征患者(实验组)和29例下唇黏液囊肿患者(对照组)的唾液,应用酶联免疫吸附试验(ELISA)检测其MMP-9的表达水平,其中实验组按照病理分级严重程度分为病理分级低的1、2级以及病理分级高的3、4级患者。结果:实验组患者唾液中MMP-9表达水平高于对照组,两组之间表达水平结果比较差异有统计学意义;病理分级高的舍格伦综合征患者组唾液中MMP-9水平高于病理分级低的患者组,两组比较差异有统计学意义。结论:唾液中MMP-9表达水平可能成为舍格伦综合征的一项检测指标,并为临床诊治提供参考依据。

Objective： To research the expression of matrix metalloprotase 9 （MMP--9） in the saliva and the rela- tionship with histopathologic grading of patients with Sjogren Syndrome. Methods： The expressions of MMP--9 in the saliva of 27 Sjogren Syndrome patients （experimental group） and 29 underlip mucocele patients （control group） were detected with ELISA and the results of Sjogren Syndrome patients were pathological graded with low level （1 and 2） and high level （3 and 4）. Results： In contrast to control group, the MMP--9 levels in Sjogren Syndrome pa- tients were significantly increased （P〈0.05）, and the level of MMP--9 in the high pathologic grade was higher than that of low grade （P〈0.05）. Conclusion： The level of MMP--9 in the saliva may be a test indicator for the Sjogren Syndrome, which might provide reference for clinical diagnosis and treatment.