中西医结合疗法对冠心病患者血脂水平及颈动脉斑块影响的比较研究

The effect of integrated Chinese-western therapy on blood lipid level and carotid artery plaque in patients with coronary heart disease

目的探讨中西医结合疗法对冠心病患者血脂水平及颈动脉斑块的影响。方法冠心病患者91例,随机分为两组,对照组45例,观察组46例。对照组使用依折麦布、瑞舒伐他汀治疗。观察组使用中草药与瑞舒伐他汀治疗。两组治疗前与治疗3个月后抽晨起静脉血检测血脂水平;彩色多普勒检查颈动脉斑块变化情况。应用SPSS20.0软件,所获数据采用方差分析、t检验和X^2检验。结果两组治疗前TC、TG、LDL-C及hs-CRP水平变化比较,P均>0.05。对照组治疗前后TC、TG、LDL-C及hs-CRP水平变化比较,P均<0.0005。观察组治疗前后TC、TG、LDL-C及hs-CRP水平变化比较,P均<0.0005。两组治疗后TC、LDL-C水平变化比较,P均<0.05;两组治疗后TG水平变化比较,P<0.005;两组治疗后hs-CRP水平变化比较,P<0.01。两组治疗前颈动脉内膜中层厚度、斑块总积分、软斑块数比较,P>0.05。对照组治疗前后颈动脉内膜中层厚度比较,P<0.005;对照组治疗前后颈动脉斑块总积分比较,P>0.05;对照组治疗前后颈动脉软斑块数比较,P<0.0005。观察组治疗前后颈动脉内膜中层厚度、软斑块数比较,P均<0.0005;观察组治疗前后颈动脉斑块总积分比较,P<0.005。两组治疗后颈动脉内膜中层厚度比较,P<0.0005;两组治疗后颈动脉斑块总积分比较,P<0.05;两组治疗后颈动脉软斑块数比较,P<0.005。两组副作用比较,P>0.05。结论单纯西药与中西医结合疗法治疗冠心病,均可有效改善患者血脂水平及颈动脉斑块情况,提升临床治疗效果,且安全性较好。但中西医结合疗法较单纯西药效果好,且不易反弹。

Objective To explore the effect of integrated Chinese-western therapy on blood lipid level and carotid plaque in patients with coronary heart disease. Methods 91 patients with coronary heart disease were randomly divided in- to two groups, 45 cases in the control group and 46 cases in the observation group. The control group was treated with ezeti- mibe and risuvastatin. The observation group was treated with herbal medicine and rishuvastatin. The blood lipid levels were detected before treatment and 3 months after treatment. Color doppler imaging was used to exam carotid artery plaque. Using SPSS20.0 software, the data obtained was analyzed by variance analysis, t test and χ^2 test. Results The comparison of TC, TG, LDL-C and hs-CRP levels between the two groups before treatment, P all 〉0.05. Comparison of TC, TG, LDL-C and hs-CRP level in the same group before treatment and 3 months after treatment were P〈0.0005. After the treatment, the changes of TC and LDL-C in the two groups were compared with P〈0.05; TG level change in the two groups was compared with P〈0.005; hs-CRP level change in the two groups was compared with P〈0.01. The comparison of carotid intima media thickness, plaque aggregate scores and the number of soft plaques between the two groups before treatment were P〉0.05. In the control group, the comparison of carotid intima media thickness before and after treatment was P〈0.005; the comparison of plaque aggregate scores was P〉0. 05; the comparison of the number of soft plaques was P〈0.0005. In the observation group, the comparison of carotid intima media thickness and plaque aggregate scores before and after treatment were P〈 0.0005; the comparison of the number of soft plaques was P〈0.005. The comparison of carotid intima media thickness between the two groups after the treatment was P〈0.0005. The comparison of plaque aggregate scores between the two groups after the treatment was P〈0.05. The comparison of the number of soft plaques between the two groups after the treatment was P〈0.005. The side effects of two groups were compared with/9〉0.05. Conclusion Both the western medicine and inte- grated Chinese-western therapy can obviously improve the blood lipid level and carotid artery plaque, improve the clinical effect and the safety is better. However, integrated Chinese-westem therapy is better than western medicine and it is not easy to rebound.