葛根芩连汤加味治疗急性感染性腹泻对血清炎性因子的影响

The effects of pueraria baicalen in treating acute infectious diarrhea on serum inflammatory cytokines

目的探讨葛根芩连汤加味治疗急性感染性腹泻对血清炎性因子的影响。方法急性感染性腹泻患者80例,随机分为两组,每组40例。对照组单纯施以西药治疗。观察组在对照组的基础上加用葛根芩连汤加味。治疗5 d,治疗前后抽晨起空腹静脉血检测血清炎性因子。应用SPSS20.0软件,所获数据采用方差分析和t检验。结果两组治疗前血清IL-6、TNF-α、CRP水平变化比较,P均>0.05。对照组治疗前后血清IL-6、TNF-α、CRP水平变化比较,P均<0.0005。观察组治疗前后血清IL-6、TNF-α、CRP水平变化比较,P均<0.0005。两组治疗后血清IL-6、TNF-α、CRP水平变化比较,P均<0.0005。两组治疗后腹痛消失、腹泻消失、退热时间比较,P均<0.0005。结论葛根芩连汤加味治疗肠道湿热证急性感染性腹泻疗效较好,炎症因子明显减轻,症状改善较快。

Objective To investigate the effect of gegen qinlian decoction on the serum inflammatory factors of acute infectious diarrhea patients. Methods 80 patients with acute infectious diarrhea were randomly divided into two groups, 40 cases in each group. The control group was only treated with western medicine. The observation group was treaed with gegen qinlian decoction on the basis of the control group. Venous blood was drawn at the morning before and 5 d after treatment. Using SPSS20.0 software, the data obtained was analyzed by variance analysis and t test. Results The comparison of IL-6, TNF-α and CRP between the two groups before treatment were all P〉0.05. The comparison of IL-6, TNF-α and CRP in the control group before and after treatment were P〈0.0005. The comparison of IL-6, TNF-α and CRP in the observation group before and after treatment were P〈0.0005. The comparison of IL-6, TNF-α and CRP between the two groups after treatment were P〈0.0005. The comparison of abdominal pain disappear, the diarrhea disappear and fever clearance time between the two groups after treatment were P〈0,0005. Conclusion The gegen qinlian decoction is effective in the treatment of acute infectious diarrhea and can obviously reduce the inflammatory factors.