中药改善EGFR-TKIs治疗进展期非小细胞肺癌产生获得性耐药的机制研究进展

Research Progress in Mechanisms of Overcoming EGFR-TKIs Acquired Resistance in Non-small-cell Lung Cancer with Traditional Chinese Medicine

表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)的临床应用在进展期非小细胞肺癌(NSCLC)治疗中具有里程碑式的意义,但在临床治疗中,很大比例的患者在接受EGFR-TKIs治疗后出现耐药。扶正解毒类中药联合EGFR-TKIs治疗进展期NSCLC在临床中疗效可观。本文综述了应用EGFR-TKIs产生耐药及扶正解毒类中药改善EGFR-TKIs耐药的相关机制,为今后深入研究及中医临床治疗提供参考。

The clinical application of epidermal growth factor receptor tyrosine kinase inhibitors （EGFR- TKIs） has milestone significance in treatment of advanced non-small cell lung cancer （NSCLC）. However, a sig- nificant proportion of patients＂ progress to acquired resistance after treated with EGFR-TKIs.TCM herbs with ef- ficacy of strengthening the body resistance and detoxification are effective in treatment of acquired resistance of EGFR-TKIs in NSCLC. This paper reviews the mechanism of acquired resistance of EGFR-TKIs and TCM herbs in improving EGFR-TKIs acquired resistance, providing a reference for future in-depth study and clinical treatment of TCM.