基于关联规则的姜良铎教授治疗肺间质纤维化组方规律探讨

Analysis on the Composing Principle of Treating Pulmonary Interstitial Fibrosis by Professor JIANG Liang-duo Based on Association Rules

目的:探讨姜良铎教授治疗肺间质纤维化的常用药物组方规律。方法:以2003年3月至2015年8月在姜良铎教授门诊就诊的肺间质纤维化患者为研究对象,对姜良铎教授治疗肺间质纤维化常用药物进行关联规则分析,探索其治疗肺间质纤维化的常用药物组方规律。结果:关联规则显示,姜良铎教授治疗肺间质纤维化组方中,置信度高的药对为赤芍、白芍;三药组合为赤芍、白芍、贝母;四药组合为赤芍、白芍、知母、贝母;五药组合为贝母、知母、紫河车、海蛤壳、水蛭;六药组合为知母、贝母、紫河车、海蛤壳、水蛭、瓜蒌。结论:姜良铎教授治疗肺间质纤维化的用药以扶正祛邪为主,扶正以补益肺、脾、肾气阴虚为主,祛邪以清肺泻热、清热化痰、活血化瘀为主。

Objective： To discuss on the commonly used drug prescription rule of Professor Jiang Liang- duo in treatment of pulmonary interstitial fibrosis. Methods： Traditional Chinese medicine compound was taken to study, which were prescribed by Professor Jiang Liang-duo Outpatient clinic from March 2003 to August 2015 to treat pulmonary interstitial fibrosis. Association rules were performed on the drug, to explore the com- monly used drug prescription rule of Professor Jiang Liang-duo in treatment of pulmonary interstitial fibrosis. Results： The couplet medicines with higher confidence in the composing principle of treating pulmonary intersti- tial fibrosis based on association rules was Radix Paeoniae Rubra, radices paeoniae alba; three drug combina- tion was Radix Paeoniae Rubra, radices paeoniae alba, Fritillaria; four drug combination was Radix Paeoniae Rubra, radices paeoniae alba, Fritillaria, Rhizoma Anemarrhenae, Placenta Hominis; five drug combination was Fritillaria, Rhizoma Anemarrhenae, Meretrix Meretrix, hirudo; six drug combination was Fritillaria, Rhizoma Anemarrhenae, Meretrix Meretrix, hirudo, Trichosanthes Kirilowii Maxim. Conclusion： The medication was mainly to rousing in treating pulmonary interstitial fibrosis. The strengthening the body resistance was mainly to tonify- ing the lung, spleen and kidney deficiency;Eliminating evil was mainly to clearing lung and eliminating phlegm, promoting blood circulation. It was helpful to find the combination of drugs which was undiscovered previously through discussing the drug law, so as to guide the combination of traditional Chinese and Western medicine treatment, improve the clinical efficacy.