舒清丸治疗肝病残留黄疸的临床效果

Clinical effect of Shuqing Pills in treating residual jaundice of liver diseases

目的观察舒清丸治疗肝病残留黄疸的临床效果。方法选择2015年3月~2017年3月河北中医肝病医院(以下简称"我院")收治的100例符合肝病残留黄疸诊断标准的患者,随机分为两组,治疗组50例(肝炎41例,肝硬化9例),对照组50例(肝炎38例,肝硬化12例)。治疗组应用舒清丸治疗,对照组应用茵栀黄颗粒治疗,30 d为1个疗程,根据病情治疗1~2个疗程。观察两组治疗前后总胆红素水平,比较两组治疗有效率,同时监测各组治疗期间的不良反应。结果治疗后两组患者总胆红素水平均有所降低(P<0.05);治疗后60 d,治疗组总胆红素水平低于对照组(P<0.05)。治疗组总有效率优于对照组(P<0.05)。亚组间总有效率比较:治疗组中硬化组、肝炎组的总有效率分别高于对照组(P<0.05),同组内肝炎组总有效率优于硬化组(P<0.05)。治疗期间治疗组有2例患者出现轻微的肠胃不适,停药后肠胃不适症状缓解,未见其他严重不良反应。结论舒清丸可以显著降低肝病残留黄疸的胆红素水平,而且不良反应较少,值得在临床推广。

Objective To observe the clinical effect of Shuqing Pills in treating residual jaundice of liver disease. Methods From March 2015 to March 2017, 100 patients diagnosed residual jaundice of liver disease in Hebei TCM Liver Disease Hospital were selected, they were randomly divided into two groups, with 50 cases in the treatment group （including 41 cases of hepatitis, 9 cases of liver cirrhosis） and 50 cases in the control group （including 38 cases of hep- atitis, 12 cases of liver cirrhosis）. The treatment group was treated with Shuqing Pills, the control group was treated with Yinzhihuang Granules. 30 days is one course of treatment, 1-2 courses of treatment according to the disease. The total bilirubin levels were observed before and after treatment, the total effective rate of the two groups were compared, Meanwhile, adverse reactions during the treatment were monitored. Results After treatment, the total bilirubin levels of the two groups were decreased （P 〈 0.05）; sixty days after treatment, the total bilirubin level of the treatment group was lower than that of the control group （P 〈 0.05）. The total effective rate of the treatment group was better than that of the control group （P 〈 0.05）. The total effective comparison in the subgroups： the rates of the cirrhosis subgroup and the hepatitis subgroup in the treatment group were better than those in the control group respectively （P 〈 0.05）; besides, the rates of the hepatitis subgroup were better than those of the cirrhosis subgroup in the same group （P 〈 0.05）. In the treatment group, two patients experienced mild gastrointestinal distress, and the gastrointestinal symptoms were relieved after discontinuation, and no other serious adverse reactions were observed. Conclusion Shuqing Pills can significantly reduce the level of bilirubin in patients with residual jaundice of liver disease, and less adverse reactions, which is worthy of clinical application.