早期高压氧治疗弥漫性轴索损伤的临床效果

Clinical effect of early hyperbaric oxygen therapy in the treatment of diffuse axonal injury

目的探讨早期高压氧治疗弥漫性轴索损伤的效果。方法选取2013年1月~2017年1月我院收治的88例弥漫性轴索损伤患者,按照随机数字表法分为对照组和观察组,每组44例。对照组患者给予对症综合治疗,观察组患者在对照组基础上,早期联合给予高压氧治疗,比较两组患者的意识状态好转率、意识平均恢复时间、清醒率及治疗6个月后的格拉斯格预后评分。结果观察组患者的意识状态好转率、清醒率均高于对照组患者,且观察组患者的意识平均恢复时间短于对照组,格拉斯格预后评分良好率显著高于对照组患者,差异有统计学意义(P<0.05)。结论弥漫性轴索损伤患者早期给予高压氧辅助治疗能够明显加速患者的意识恢复和苏醒,预后良好,具有一定的临床应用价值。

Objective To disscuss the effect of early hyperbaric oxygen therapy in the treatment of diffuse axonal injury. Methods 88 cases of diffuse axonal injury in our hospital from January 2013 to January 2017 were selected and divid- ed into the control group and the observation group according to the random number table method,44 cases in each group.The control group was treated with symptomatic comprehensive treatment,the observation group was treated with hyperbaric oxygen in the early stage on the basis of the control group.The improvement of consciousness state,con- sciousness average recovery time,the sober rate and Grasg＇s prognosis score after 6 months of treatment were compared between the two groups.Results The rate of consciousness improvement and the sober rate of the observation group was higher than that of the control group,moreover,the consciousness average recovery time of the patients in the observation group was significantly shorter than that in the control group,and the good rate of the Grasg＇s prognosis in the observa- tion group was significantly higher than that in the control group,with significant difference （P〈0.OS）.Conclusion Early hyperbaric oxygen adjuvant therapy in patients with diffuse axonal injury can significantly accelerate consciousness re- covery and resuscitation,which has good prognosis and has certain clinical application value.