盐酸替罗非班对急性心肌梗死急诊经皮冠状动脉介入治疗的临床价值

Clinical value of Tirofiban Hydrochloride in emergency percutaneous coronary intervention in patients with acute myocardial

目的探讨盐酸替罗非班对急性心肌梗死急诊经皮冠状动脉介入治疗的临床价值。方法选取本院2014年8月~2016年8月行急性心肌梗死急诊经皮冠状动脉介入治疗的112例患者,采用随机数字表法分为对照组和观察组,各56例。对照组患者实施常规治疗,观察组患者联用盐酸替罗非班治疗,比较两组患者的血流情况、心功能、指标复常时间、不良事件。结果治疗后,两组患者梗死相关血管TIMI血流、心功能改善(P<0.05),观察组患者梗死相关血管TIMI血流改善、心功能改善优于对照组(P<0.05)。观察组患者的ST段恢复时间、心肌酶酶峰出现时间早于对照组(P<0.05),住院时间短于对照组(P<0.05)。观察组患者的不良事件发生率(术中慢血流、再灌注心律失常、出血、血小板降低)低于对照组(P<0.05)。结论急性心肌梗死急诊经皮冠状动脉介入治疗时,盐酸替罗非班可改善患者TIMI血流和心功能,降低不良事件的发生风险。

Objective To investigate clinical value of Tirofibau Hydrochloride in emergency percutaneous coronary in- tervention in patients with acute myocardial.Methods 112 patients with acute myocardial treated emergency pereuta- neous coronary intervention in our hospital from August 2014 to August 2016 were selected and divided into the control group and the observation group according to random number table method,56 cases in each group.The control group was treated with conventional treatment,the observation group was given combination with Tirofiban Hydrochloride.The condition of blood flow,cardiac function,indicator repeat time,adverse events were compared between two groups.Results After treatment,TIMI blood flow of infarct related vessels and cardiac function improved in the two groups （P〈0.05）.TI- MI blood flow of infarct related vessels and cardiac function improvement in the observation group after treatment were better than those in the control group （P〈0.05）.Recovery time of ST segment,occurrence time of myocardial enzyme peak in the observation group were earlier than those in the control group （P〈0.05）.Hospitalization time in the observation group was less than that in the control group （P〈0.05）.The incidence of adverse events （intraoperative slow flow,reperfusion arrhythmia,bleeding,thrombocytopenia） in the observation group were lower than those in the control group （P〈0.05）. Conclusion As emergency percutaneous coronary intervention in patients with acute myocardial,tirofiban hydrochloride can improve TIMI blood flow and cardiac function.which can also reduce the risk of adverse events.