嗜人T淋巴细胞病毒Ⅰ型感染所致葡萄膜炎基础研究的新进展

New progress in basic research of uveitis caused by human T lymphocyte leukemia virus type Ⅰ infection

嗜人T淋巴细胞病毒(HTLV)是一种逆转录病毒,目前发现有3种亚型,即HTLV-Ⅰ、HTLV-Ⅱ及HTLV-Ⅲ。HTLV-Ⅰ与成人T细胞白血病(ATL)、HTLV-Ⅰ相关性脊髓病(HAM)及葡萄膜炎有关。HTLV-Ⅰ感染后不仅能够引发葡萄膜炎,同时也可能引起多种其他眼部疾病。目前,国内外大多数学者认为,HTLV-Ⅰ感染所致的葡萄膜炎(HAU)是由于HTLV-Ⅰ感染体内的T淋巴细胞,导致被感染的细胞因子聚集在眼内,从而引起的眼部炎症反应。本文中笔者对HAU的发病机制、临床特征、诊断方法、治疗手段及与其他疾病之间的关系进行综述。

Human T lymphotropic virus（ HTLV） is a retrovirus that currently has 3 subtypes,namely HTLV-Ⅰ and HTLV-Ⅱ and HTLV-Ⅲ,HTLV-Ⅰ and adult T cell leukemia（ ATL）,HTLV-Ⅰassociated myelopathy（ HAM） and uveitis on. HTLV-Ⅰ infection can not only cause uveitis,but also may cause a variety of other ocular symptoms. At present,most scholars believe that HTLV-Ⅰ infection induced uveitis（ HAU） is due to the infection of HTLV-Ⅰ T lymphocytes in vivo,leading to cytokine infection gathered in the eye,causing inflammation of the eye. In this paper,the pathogenesis,clinical features,diagnostic methods,treatment methods and the relationship between HAU and other diseases are reviewed.