1XuJ, Zhang X, Pelayo R, et al. Extracellular histones are major medi- ators of death in sepsis[J].Nat Med,2009,15(11) :1318-1321.
2Berger SL. The complex language of chromatin regulation during transcription[J]. Nature,2007 ,447 (7143) :407412.
3Papayannopoulos V, Zychlinsky A. NETs: a new strategy for using old weapons[J]. Trends Immunol,2009,30(11) :513-521.
4Holdenrieder S, Stieber P. Clinical use of circulating nucleosomes[J].Crit Rev Clin Lab Sci,2009,46(I) :1-24.
5Margraf S, Logters T, ReipenJ, et al. Neutrophil-derived circulating free DNA ( cf-DNAINETs): a potential prognostic marker for postt?raumatic development of inflammatory second hit and sepsis[J] . Shock,2008 ,30( 4) :352-358.
6XuJ , Zhang X, Monestier M, et al. Extracellular histones are media?tors of death through TLR2 and TLR4 in mouse fatal liver injury[J].J Immunol,2011 ,187(5) :2626-2631.
7Huang H,EvankovichJ, Yan W,et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like re?ceptor 9 in mice[J]. Hepatology ,2011 ,54( 3) :999-1008.
8Allam R, Scherbaum CR, Darisipudi MN, et al. Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4[J] .J Am Soc Nephrol,2012,23 (8) :1375-1388.
9TschoppJ, Schroder K. NLRP3 inflammasome activation: The con?vergence of multiple signalling pathways on ROS production?[J]. Nat Rev Immunol,2010,10(3) :210-215.
10Huang H, Chen HW, EvankovichJ, et al. Histones activate the NL?RP3 inflammasome in kupffer cells during sterile inflammatory liver injury[J].J Immunol,2013,191 (5) :2665-2679.
