基于二维超声心动图心肌分层应变技术评估HeFH患者左心室功能

Assessment of left ventricular function in HeFH patients with myocardial layer-specific analysis based on two-dimensional echocardiography

目的观察分层应变技术评估射血分数正常的亚临床症状杂合子型FH(HeFH)患者左心室功能的价值。方法收集确诊为HeFH并行经胸超声心动图检查的患者34例(HeFH组),另收集同期29名健康志愿者为对照组。采用EchoPAC软件,获得心内膜层纵向应变(LS_(endo))、心肌层纵向应变(LS_(myo))和心外膜层纵向应变(LS_(epi)),并进行统计学分析。结果 HeFH组LS_(endo)和LS_(myo)显著低于对照组(P<0.001)。LS_(endo)和LS_(myo)与血浆总胆固醇、低密度脂蛋白胆固醇水平呈负相关(P均<0.05)。结论分层评估左心室应变在分析HeFH患者早期心肌损伤方面有重要价值。

Objective To explore the value of layer-specific strain in assessment of left ventricular function in patients with heterozygous familial hypercholesterolemia （HeFH） with normal left ventricular ejection fraction （LVEF）. Methods Thirty-four patients with diagnosed HeFH and underwent transthoracic echocardiography were included as HeFH group, while 29 healthy volunteers were taken as control group. EchoPAC software was used to obtain endocardial longitudinal strain （LSendo）, myocardial longitudinal strain （LSmyo） and epicardial longitudinal strain （LSepl） of the epicardial, and then statistical analysis was performed. Results LSondo and LSmyo in HeFH group were significantly lower than those in control group （P〈0. 001）. LSendo and LSmyo were negatively correlated with total cholesterol and low density lipoprotein cholesterol （all P〈0.05）. Conclusion Layer-specific strain of left ventricular is of great value in assessing early myocardial damage in patients with HeFH.