基于数据挖掘的早期糖尿病肾病中医治疗用药规律研究

The Medication Rule of TCM Medicine Treatment for Early Diabetic Nephropathy Base on Data Mining

目的:基于文献探究早期糖尿病肾病中医治疗用药规律。方法:检索并筛选中国期刊全文数据库自建库以来至今早期糖尿病肾病的中医治疗相关文献,建立中医治疗早期糖尿病肾病的文献研究数据库,运用频数分析、聚类分析以及关联分析等数据挖掘方法对用药规律进行探究,进一步指导临床用药。结果:中医治疗早期糖尿病肾病的文献中所含中药复方104首,中药129味,药物种类以补虚药、活血化瘀药、清热药、利水渗湿药和收涩药为主;药物性味以甘、苦为主,药性多为寒、平;归经以肝经、肾经为主。对高频药物进行聚类分析结果得出4个聚类组合,另外对所涉及的中药进行关联规则分析,得到药对规则17条,药组(3味药、4味药)规则36条。结论:中医治疗早期糖尿病肾病,药物性味以甘苦为主,归肝肾两经,核心单味药为黄芪、丹参、生地黄等,临床治疗方法以益气养阴,活血化瘀,清热利湿为主。

Objective： To explore the medication rule of TCM medicine treatment for early diabetic nephropathy base on literature. Methods： We searched and identified the clinical study literature in China Journal Full-text Database about early diabetic nephropathy so far since the selfbuilt database and established a database, using data mining （frequency analysis, cluster analysis and association rule analysis） to discuss the medication rule of TCM medicine treatment, in order to guide the clinical medication. Results： The clinical study literature about TCM medicine treatment for early diabetic nephropathy included 104 prescriptions and 129 herbs, and the most commonly used drugs were deficiency-nourishing drugs, blood circulation drugs, heat clearing drugs, inhibiting-damp drugs and astringent medicinal. Medication was mainly sweet and bitter; and liver and kidney meridian tropism. Cluster analysis results showed that high-frequency selected herbs got four clusters of combinations. By using association rule analysis, the rule in pair of herbs were 17, and rule in group of herbs were 36 （three or four medicinal herbs）. Conclusion： The medication rule of TCM medicine treatment for early diabetic nephropathy is that medication is mainly sweet and bitter, and liver and kidney meridian tropism; the core herbs are huangqi （Astragalus membranaceus）, danshen （Salvia miltiorrhiza） , shengdihuang （Rehmannia glutinosa） and so on. Clinical treatment is mainly supplementing qi and nourishing yin, promoting blood circulation for blood stasis, clearing heat and removing dampness.