外周血指标检测在急性出血性脑卒中深静脉血栓中的诊断价值

Diagnostic Value of Peripheral Blood Detection in Deep Vein Thrombosis in Acute Hemorrhagic Cerebral Stroke

目的探讨外周血指标检测在急性缺血性脑卒中(AIS)深静脉血栓(DVT)中的诊断价值。方法根据血栓形成情况,将410例AIS患者分为血栓组(n=210)和无血栓组(n=200),另将180例体检健康者设为对照组,检测各组外周血P-选择素、D-二聚体、同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平。结果血栓组平均年龄明显高于无血栓组(P<0.05);血栓组D-二聚体、P-选择素水平均明显高于无血栓组与对照组(P<0.05);血栓组的hs-CRP水平明显高于对照组(P<0.05);无血栓组的D-二聚体、P-选择素及hs-CRP水平明显高于对照组(P<0.05);三组Hcy水平无明显差异(P>0.05)。联合应用后,检测的灵敏度为70.6%,特异度为96.6%。结论 P-选择素和D-二聚体联合检测在诊断AIS DVT方面具有较高价值。

OBJECTIVE To explore the diagnostic value of peripheral blood detection in deep vein thrombosis （DVT） in acute hemorrhagic cerebral stroke （AIS）. METHODS A total of 410 patients with AIS were divided into thrombus group （n=210） and non-thrombus group （n=200） according to the formation of thrombus, and another 180 healthy people undergoing physical examinations served as control group. The levels of P-selectin, D-dimer （D-D）, homocysteine （Hey） and high-sensitivity C-reactive protein （hs-CRP） in the peripheral blood of all groups were detected. RESULTS Thrombus group were evidently higher in average age （P〈0.05）, and notably higher in the levels of D-D and P- selectin than non-thrombus group （P〈0.05）. Thrombus group was prominently higher in the level of hs-CRP than control group （P〈0.05）, while non-thrombus group was significantly higher in D-D, P- selectin and hs-CRP levels than control group （P〈0.05）. There was insignificant difference among three groups in Hcy level （P〉0.05）. After combined application, the sensitivity and specificity of detection was 70.6% and 96.6%, respectively. CON- CLUSION Combined detection of P- selectin and D-D had higher value in the diagnosis of AIS DVT.