摘要
毛冬青甲素(ilexonin A)是从冬青科植物毛冬青中分离出的一种有效成分,分子式为C_(34)H_(48)O_6Na,临床上初步试用于治疗脑血栓、心肌梗塞等心血管疾病。药理实验表明,毛冬青甲素在体外有抗血栓形成,抑制血小板粘附、聚集和释放功能及抑制TXA_2样物质的生成。最近研究结果表明。
Arachidonic acid (AA) and prostaglandin endoperoxide were used as substrates and pig lung microsomes provided enzymes to determine thromboxane Bt (TXB2) and 6-keto-PGF1α levels in a study of the effects of ilexonin A and verapamil on the activities of cyclooxygenase, thromboxane A2 synthetase and prostacyclin synthetase in the AA metabolic pathway . The results indicated that both ilexonin A and verapamil inhibited the activities of all three enzymes. The inhibitory effect of verapamil on thromboxane A2 synthetase was stronger than that on prostacyclin synthetase. The activity of the latter was not inhibited by verapamil in concentrations lower than 100μmol/L.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第2期148-151,共4页
Acta Academiae Medicinae Sinicae
